Authorship and contributorship: Gunnar Svensson designed and performed the study, collected and analysed the data and wrote the paper. Sven-Börje Ewers performed the study and analysed the data. Ola Ohlsson designed the study, analysed the data and wrote the paper. Håkan Olsson analysed the data.
Prognostic factors in lung cancer in a defined geographical area over two decades with a special emphasis on gender
Article first published online: 18 APR 2012
© 2012 Blackwell Publishing Ltd
The Clinical Respiratory Journal
Volume 7, Issue 1, pages 91–100, January 2013
How to Cite
Svensson, G., Ewers, S.-B., Ohlsson, O. and Olsson, H. (2013), Prognostic factors in lung cancer in a defined geographical area over two decades with a special emphasis on gender. The Clinical Respiratory Journal, 7: 91–100. doi: 10.1111/j.1752-699X.2012.00289.x
Ethics: The research project was approved by the Ethical Committee, Lund University (reg.nr.2009/225), Sweden.
Conflict of interest: The authors have stated explicitly that there are no conflicts of interest in connection with this article.
- Issue published online: 26 MAR 2013
- Article first published online: 18 APR 2012
- Accepted manuscript online: 1 MAR 2012 10:32AM EST
- Received: 09 November 2011; Revision requested: 30 January 2012; Accepted: 27 February 2012
- prognostic factor;
Introduction: Many studies over recent decades report an increasing incidence of lung cancer in female patients. Female gender is often reported as a good prognostic factor.
Objectives: The aim of the present study was to investigate prognostic factors with a special emphasis on gender.
Methods: During 1989–2008, 1497 patients in eastern Scania, a part of southern Sweden with 202 000 inhabitants, were referred to one Central Hospital and prospectively registered. All patients were grouped into four 5-year periods and were analysed for occurrence of lung cancer, patient performance status, types and stages of lung cancer and the relation to gender.
Results: The incidence of lung cancer more than doubled in women. The proportion of adenocarcinomas increased in females and in males to 57% (P = 0.028) and 42% (P = 0.001), respectively, while the frequency of small cell lung carcinomas (SCLCs) decreased in both genders to approximately 14%. Females had significantly more frequent stage 1 (16.6%) and higher surgery rate (23.1%) than males (12% and 18.2%, respectively). Females showed a higher 5-year survival rate than males (20.1% and 11.5%, respectively; P < 0.001). Patients with non-small cell lung carcinoma (NSCLC) had a higher 5-year survival rate than those with SCLC (16.5% and 7.5%, respectively; P < 0.01); however, there was no significant survival difference in females between NSCLC and SCLC.
Conclusion: Female patients exhibited longer survival than males for both NSCLC and SCLC, and this was not explained by a higher frequency of stage 1 or surgery in NSCLC.
Please cite this paper as: Svensson G., Ewers S.-B., Ohlsson O. and Olsson H. Prognostic factors in lung cancer in a defined geographical area over two decades with a special emphasis on gender. Clin Respir J 2013; 7: 91–100.