Authorship and contributorship
Value of cytologic analysis of bronchial washings in lung cancer on the basis of bronchoscopic appearance
Version of Record online: 19 JUN 2012
© 2012 Blackwell Publishing Ltd
The Clinical Respiratory Journal
Volume 7, Issue 2, pages 128–134, April 2013
How to Cite
Lee, G. D., Kim, H. C., Kim, Y. E., Lee, S. J., Cho, Y. J., Jeong, Y. Y., Jeon, K.-N., Jang, I. S., Lee, J. D. and Hwang, Y. S. (2013), Value of cytologic analysis of bronchial washings in lung cancer on the basis of bronchoscopic appearance. The Clinical Respiratory Journal, 7: 128–134. doi: 10.1111/j.1752-699X.2012.00293.x
GD Lee reviewed the bronchoscopy report, registered the radiologic and pathologic information provided, performed the statistical analysis, and wrote the manuscript. YE Kim, SU Lee, YY Jeong, YJ Cho, JD Lee and YS Hwang performed bronchoscopy as pulmonology specialists. KN Jeon reported radiologic findings and IS Jang assisted in pathologic confirmation of difficult-to-diagnose cases as surgeon. HC Kim conducted the study and revised the manuscript.
The study was approved by the appropriate ethics review boards (Gyeongsang University Hospital International Review Board). The approved study code number is GNUHIRB-2011-037.
Conflict of interest
The authors have stated explicitly that there are no conflicts of interest in connection with this article.
- Issue online: 22 APR 2013
- Version of Record online: 19 JUN 2012
- Accepted manuscript online: 9 MAY 2012 02:12AM EST
- Received: 28 June 2011; Revision requested: 17 March 2012; Accepted: 18 April 2012
- bronchial washing;
- lung cancer
Introduction: We evaluated the diagnostic yield of cytologic analysis of bronchial washing in addition to forceps biopsy on the basis of bronchoscopic appearance and histologic type in lung cancer.
Methods: This retrospective study included 611 patients who had lung cancer and underwent bronchoscopic procedures between April 2003 and December 2008. Bronchoscopic appearance was classified into six types (tumor, infiltrative, necrotic, normal, compressive and aspecific) on the basis of endoscopic morphology.
Results: The forceps biopsy were positive in 492 cases (80.5%), and the diagnostic yield of the combination of forceps biopsy with cytologic analysis of bronchial washing was 84.1% (514/611 cases), that is, a statistically significant increase of 3.6% (P < 0.001). Washing cytologic analysis in the case of tumor, infiltrative and necrotic lesions had higher diagnostic yields than that in the case of normal, compressive and aspecific lesions (41.7% vs 29.3%), but its diagnostic yield did not increase on combination with forceps biopsy (P > 0.05). However, in the case of normal and compressive lesions, the addition of forceps biopsy to washing cytologic analysis significantly increased the diagnostic yield (P < 0.05). The histologic type of lung cancer did not significantly affect the difference in diagnostic yield between forceps biopsy alone and the combination of forceps biopsy and washing cytologic analysis (P > 0.05).
Conclusions: The combination of forceps biopsy and washing cytologic analysis offers a better diagnostic yield than biopsy alone in diagnosing lung cancer. Both procedures should be performed during bronchoscopy even if no endobronchial lesion is present.
Please cite this paper as: Lee GD, Kim HC, Kim YE, Lee SJ, Cho YJ, Jeong YY, Jeon K-N, Jang IS, Lee JD and Hwang YS. Value of cytologic analysis of bronchial washings in lung cancer on the basis of bronchoscopic appearance. Clin Respir J 2013; 7: 128–134.