Get access

The effect of mold sensitization and humidity upon allergic asthma

Authors

  • Don Hayes, Jr,

    Corresponding author
    1. Departments of Pediatrics and Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA
      Don Hayes, Jr, MD, MS, MEd, The Ohio State University College of Medicine, 700 Children's Drive, 43205 Columbus, OH, USA. Tel: +1 614 722 3425, Fax: +1 614 722 3426, email: hayes.705@osu.edu
    Search for more papers by this author
  • Manan A. Jhaveri,

    1. Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY, USA
    Search for more papers by this author
  • David M. Mannino,

    1. Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY, USA
    Search for more papers by this author
  • Heather Strawbridge,

    1. Department of Pediatrics, Northeast Ohio Medical University College of Medicine, Rootstown, OH, USA
    Search for more papers by this author
  • James Temprano

    1. Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA
    Search for more papers by this author

  • Authorship and contributorship Dr Hayes participated in study design, analyzed data and wrote the manuscript. Mr Jhaveri participated in study design and collected data. Dr Mannino participated in study design, analyzed data and edited the manuscript. Dr Strawbridge analyzed data and edited the manuscript. Dr Temprano participated in study design, analyzed data and edited the manuscript.

  • Ethics This study was approved by the Institutional Review Board in accordance with the ethical standards laid down by the appropriate version of the 2000 Declaration of Helsinki.

  • Conflict of interest The authors have stated explicitly that there are no conflicts of interest in connection with this article.

  • Declaration of interests The authors disclose no financial, consulting or personal relationships with other people or organizations that could influence or bias this work. Furthermore, there was no financial support for completion of this study or development of this manuscript. Employment for each author is the listed affiliation as outlined on the title page. The manuscript represents original work that is not being currently considered or has been accepted for publication elsewhere.

Don Hayes, Jr, MD, MS, MEd, The Ohio State University College of Medicine, 700 Children's Drive, 43205 Columbus, OH, USA. Tel: +1 614 722 3425, Fax: +1 614 722 3426, email: hayes.705@osu.edu

Abstract

Introduction:  Humidity is commonly associated with increased airway hyperresponsiveness in asthma.

Objective:  To examine mold sensitization in patients with allergic asthma or allergic rhinitis and self-reports of humidity as exacerbating factors of clinical symptoms.

Methods:  A retrospective, cross-sectional study at a University hospital outpatient allergy and asthma clinic was performed. A total of 106 patients with either allergic asthma or allergic rhinitis completed standard prick-puncture skin testing with 17 allergens and controls and completed standardized forms addressing trigger factors for clinical symptoms.

Results:  Allergic asthmatics sensitized to Cladosporium were more likely to have a more severe asthma severity class (odds ratio = 4.26, confidence interval = 1.30–16.93). Sensitization to Alternaria, Cladosporium, Helminthosporium, Aspergillus and Dermatophagoides pteronyssinus in asthma was associated with higher likelihood for previous hospitalization, while sensitization to Cladosporium, Helminthosporium, Aspergillus, Dermatophagoides pteronyssinus and cockroach in asthma was associated with higher likelihood of having reduced pulmonary function based on forced expiratory volume in 1 s. Furthermore, allergic asthmatics more commonly reported humidity as an exacerbating factor of symptoms than did patients only with allergic rhinitis (68.42% vs 42.86%, respectively; P < 0.05).

Conclusion:  Mold sensitization is highly associated with more severe asthma, while humidity is more of an exacerbating factor in patients with allergic asthma as compared with allergic rhinitis alone. Further delineation between mold sensitization and humidity is needed to determine whether these are independent factors in asthma.

Please cite this paper as: Hayes D Jr, Jhaveri MA, Mannino DM, Strawbridge H and Temprano J. The effect of mold sensitization and humidity upon allergic asthma. Clin Respir J 2013; 7: 135–144.

Get access to the full text of this article

Ancillary