• 1
    Taylor DR, Pijnenburg MW, Smith AD, De Jongste JC. Exhaled nitric oxide measurements: clinical application and interpretation. Thorax. 2006;61(9): 817827.
  • 2
    Berkman N, Avital A, Breuer R, Bardach E, Springer C, Godfrey S. Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests. Thorax. 2005;60(5): 383388.
  • 3
    Cardinale F, de Benedictis FM, Muggeo V, Giordano P, Loffredo MS, Iacoviello G, Armenio L. Exhaled nitric oxide, total serum IgE and allergic sensitization in childhood asthma and allergic rhinitis. Pediatr Allergy Immunol. 2005;16(3): 236242.
  • 4
    Janson C, Kalm-Stephens P, Foucard T, Norbäck D, Alving K, Nordvall SL. Exhaled nitric oxide levels in school children in relation to IgE sensitisation and window pane condensation. Respir Med. 2005;99(8): 10151021.
  • 5
    Syk J, Undén AL, Alving K. Relationship between exhaled nitric oxide and IgE sensitisation in patients with asthma: influence of steroid treatment. Clin Respir J. 2009;3(3): 143151.
  • 6
    Mattes J, Storm Van's Gravesande K, Reining U, Alving K, Ihorst G, Henschen M, Kuehr J. NO in exhaled air is correlated with markers of eosinophilic airway inflammation in corticosteroid-dependent childhood asthma. Eur Respir J. 1999;13(6): 13911395.
  • 7
    Choi J, Hoffman LA, Rodway GW, Sethi JM. Markers of lung disease in exhaled breath: nitric oxide. Biol Res Nurs. 2006;7(4): 241255.
  • 8
    Van Den Toorn L, Overbeek S, De Jongste J, Leman K, Hoogsteden H, Prins J. Airway inflammation is present during clinical remission of atopic asthma. Am J Respir Crit Care Med. 2001;164(11): 21072113.
  • 9
    Kharitonov SA, Donnelly LE, Montuschi P, Corradi M, Collins JV, Barnes PJ. Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma. Thorax. 2002;57(10): 889896.
  • 10
    Silkoff PE, McClean P, Spino M, Erlich L, Slutsky AS, Zamel N. Dose-response relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients. Chest. 2001;119(5): 13221328.
  • 11
    Silkoff PE, McClean PA, Slutsky AS, Caramori M, Chapman KR, Gutierrez C, Zamel N. Exhaled nitric oxide and bronchial reactivity during and after inhaled beclomethasone in mild asthma. J Asthma. 1998;35(6): 473479.
  • 12
    Lim KG, Mottram C. The use of fraction of exhaled nitric oxide in pulmonary practice. Chest. 2008;133(5): 12321242.
  • 13
    Alving K, Malinovschi A. Basic aspects of exhaled nitric oxide, in European Respiratory Monograph 2010.
  • 14
    Stanojevic S, Wade A, Stocks J. Reference values for lung function: past, present and future. Eur Respir J. 2010;36(1): 1219.
  • 15
    Daly L, Bourke GJ. Interpretation and Uses of Medical Statistics. Oxford, Wiley-Blackwell, 2000.
  • 16
    Sackett DL, Haynes RB. The architecture of diagnostic research. BMJ. 2002;324(7336): 539541.
  • 17
    Smith AD, Cowan JO, Taylor DR. Exhaled nitric oxide levels in asthma: personal best versus reference values. J Allergy Clin Immunol. 2009;124(4): 714718.e4.
  • 18
    ATS/ERS. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005;171(8): 912930.
  • 19
    Levesque MC, Hauswirth DW, Mervin-Blake S, Fernandez CA, Patch KB, Alexander KM, Allgood S, McNair PD, Allen AS, Sundy JS. Determinants of exhaled nitric oxide levels in healthy, nonsmoking African American adults. J Allergy Clin Immunol. 2008;121(2): 396402 e3.
  • 20
    Maestrelli P, Ferrazzoni S, Visentin A, Marian E, Dal Borgo D, Accordino R, Fabbri LM. Measurement of exhaled nitric oxide in healthy adults. Sarcoidosis Vasc Diffuse Lung Dis. 2007;24(1): 6569.
  • 21
    Lundberg J, Weitzberg E, Lundberg J, Alving K. Nitric oxide in exhaled air. Eur Respir J. 1996;9(12): 2671.
  • 22
    Pedroletti C, Högman M, MeriLäinen P, Nordvall LS. Nitric oxide airway diffusing capacity and mucosal concentration in asthmatic schoolchildren. Pediatr Res. 2003;54(4): 496501.
  • 23
    Gelb AF, George SC, Camacho F, Fraser C, Flynn Taylor C, Shakkottai S. (2011). Increased Nitric Oxide Concentrations in the Small Airway of Older Normal Subjects. CHEST Journal , 139(2), 368-375. doi: 10.1378/chest.10-1157
  • 24
    Olin A-C, Bake B, Torén K. Fraction of exhaled nitric oxide at 50 mL/s: reference values for adult lifelong never-smokers. Chest. 2007;131(6): 18521856.
  • 25
    Taylor DR, Mandhane P, Greene JM, Hancox RJ, Filsell S, McLachlan CR, Williamson AJ, Cowan JO, Smith AD, Sears, MR. Factors affecting exhaled nitric oxide measurements: the effect of sex. Respir Res. 2007;8: 82.
  • 26
    Travers J, Marsh S, Aldington S, Williams M, Shirtcliffe P, Pritchard A, Weatherall M, Beasley, R. Reference ranges for exhaled nitric oxide derived from a random community survey of adults. Am J Respir Crit Care Med. 2007;176(3): 238242.
  • 27
    Kovesi T, Dales R. Exhaled nitric oxide and respiratory symptoms in a community sample of school aged children. Pediatr Pulmonol. 2008;43(12): 11981205.
  • 28
    Kovesi T, Kulka R, Dales R. Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children. Chest. 2008;133(1): 169175.
  • 29
    Sandrini A, Taylor DR, Thomas PS, Yates DH. (2010). Fractional exhaled nitric oxide in asthma: an update. Respirology. 15(1): 5770.
  • 30
    Olin A-C, Rosengren A, Thelle DS, Lissner L, Bake B, Torén K. Height, age, and atopy are associated with fraction of exhaled nitric oxide in a large adult general population sample. Chest. 2006;130(5): 13191325.
  • 31
    Olin A-C, Bake B, Torén K. Fraction of exhaled nitric oxide at 50 mL/s: reference values for adult lifelong never-smokers. Chest. 2007;131(6): 18521856.
  • 32
    Kumar R, et al. Genetic ancestry in lung-function predictions. N Engl J Med. 2010;363(4): 321330.
  • 33
    de Gouw H, Grunberg K, Schot R, Kroes A, Dick E, Sterk P. Relationship between exhaled nitric oxide and airway hyperresponsiveness following experimental rhinovirus infection in asthmatic subjects. Eur Respir J. 1998;11(1): 126132.
  • 34
    Baraldi E, Carra S, Dario C, Azzolin N, Ongaro R, Marcer G, Zacchello F. Effect of natural grass pollen exposure on exhaled nitric oxide in asthmatic children. Am J Respir Crit Care Med. 1999;159(1): 262266.
  • 35
    Bodini A, Peroni D, Loiacono A, Costella S, Pigozzi R, Baraldi E, Boner AL, Piacentini GL. Exhaled nitric oxide daily evaluation is effective in monitoring exposure to relevant allergens in asthmatic children. Chest. 2007;132(5): 15201525.
  • 36
    Gabriele C, Pijnenburg MW, Monti F, Hop W, Bakker ME, de Jongste JC. The effect of spirometry and exercise on exhaled nitric oxide in asthmatic children. Pediatr Allergy Immunol. 2005;16(3): 243247.
  • 37
    Verges S, Tonini J, Flore P, Favre-Juvin A, Levy P, Wuyam B. Exhaled nitric oxide in single and repetitive prolonged exercise. J Sports Sci. 2006;24(11): 11571163.
  • 38
    Nickmilder M, de Burbure C, Carbonnelle S, Dumont X, Bernard A, Derouane A. Increase of exhaled nitric oxide in children exposed to low levels of ambient ozone. J Toxicol Environ Health A. 2007;70(3–4): 270274.
  • 39
    Olin AC, Stenfors N, Toren K, Blomberg A, Helleday R, Ledin MC, Ljungkvist G, Ekman A, Sandstrom T. Nitric oxide (NO) in exhaled air after experimental ozone exposure in humans. Respir Med. 2001;95(6): 491495.
  • 40
    Delfino RJ, Staimer N, Gillen D, Tjoa T, Sioutas C, Fung K, George SC, Kleinman MT. Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma. Environ Health Perspect. 2006;114(11): 17361743.
  • 41
    Alving K, Janson C, Nordvall L. Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children. Respir Res. 2006;7: 67.
  • 42
    (NCHS)., C.f.D.C.a.P.C.N.C.f.H.S. National Health and Nutrition Examination Survey Data . 2011. Available at: (accessed 21 Nov 2011).
  • 43
    ATS. Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children-1999. Am J Respir Crit Care Med. 1999;160(6): 21042117.