This research was supported by grants DE12102, HL34595, HL35464, CA87969, and CA55075 from the National Institute of Health, and by the Office of Dietary Supplements.
The Association Between Tooth Loss and Coronary Heart Disease in Men and Women
Article first published online: 1 MAY 2007
Journal of Public Health Dentistry
Volume 64, Issue 4, pages 209–215, December 2004
How to Cite
Hung, H.-C., Joshipura, K. J., Colditz, G., Manson, J. E., Rimm, E. B., Speizer, F. E. and Willett, W. C. (2004), The Association Between Tooth Loss and Coronary Heart Disease in Men and Women. Journal of Public Health Dentistry, 64: 209–215. doi: 10.1111/j.1752-7325.2004.tb02755.x
- Issue published online: 1 MAY 2007
- Article first published online: 1 MAY 2007
- Manuscript received: 12/24/03; returned to authors for revisions: 3/17/04; final version accepted for publication: 5/19/04.
- myocardial infarction;
- coronary heart disease;
- periodontal disease;
- tooth loss;
- cardiovascular disease;
Objectives: This paper evaluates the relation of tooth loss to incidence of coronary heart disease in two large cohort studies. Methods: Participants included 41,407 men and 58,974 women free of any cardiovascular diseases at baseline. We recorded 1,654 incident coronary heart disease events (562 fatal events) among men during 12 years of follow-up and 544 events (158 fatal events) among women during 6 years of follow-up. Results: After controlling for important cardiovascular risk factors, compared to men with 25–32 teeth at baseline, men with 0–10 teeth had a significantly higher risk of coronary heart disease (relative risk [RR]/1.36; 95 percent confidence interval [CI]/1.11, 1.67). The relative risk increased to 1.79 (95% CI/1.34, 2.40) when limited to fatal events. Women with 0–10 teeth were also at increased risk of coronary heart disease compared to women with 25–32 teeth (RR/1.64; 95% CI/1.31, 2.05). The association was similar for fatal events (RR/1.65; 95% CI=1.11, 2.46). The association between number of teeth and incidence of coronary heart disease was similar between men with and without a history of periodontal disease, and there was no significant association between tooth loss during follow-up and coronary heart disease. Conclusions: This study showed a significant association between number of teeth at baseline and risk of coronary heart disease and the mechanisms to explain this association should be further clarified. [J Public Health Dent 2004;64(4):209–15]