Overexpression of Matrix Metalloproteinase 9 in Tumor Epithelial Cells Correlates with Colorectal Cancer Metastasis
Article first published online: 10 SEP 2008
© 2008 Wiley Periodicals, Inc.
Clinical and Translational Science
Volume 1, Issue 2, pages 136–141, September 2008
How to Cite
Zuzga, D. S., Gibbons, A. V., Li, P., Lubbe, W. J., Chervoneva, I. and Pitari, G. M. (2008), Overexpression of Matrix Metalloproteinase 9 in Tumor Epithelial Cells Correlates with Colorectal Cancer Metastasis. Clinical and Translational Science, 1: 136–141. doi: 10.1111/j.1752-8062.2008.00037.x
- Issue published online: 10 SEP 2008
- Article first published online: 10 SEP 2008
- colorectal cancer;
- disease stage
Colorectal cancer mortality largely reflects metastasis, the spread of the disease to distant organs. Matrix metalloproteinase 9 (MMP-9) is a key regulator of metastasis and a target for anticancer strategies in colon cancer. Here, the overexpression of MMP-9 in pure tumor epithelial, but nor stromal, cell populations was associated with metastatic progression of colorectal cancer, as defined by reverse transcriptase-polymerase chain reaction (qRT-PCR) and confirmed by immunostaining. Thus, cancer cell MMP-9 represents a novel, selective prognostic and predictive factor that may be exploited for more effective disease stage stratification and therapeutic regimen selection in patients with colorectal cancer.