Genetics of type 2 diabetes in European populations
Article first published online: 17 AUG 2012
© 2012 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd
Journal of Diabetes
Volume 4, Issue 3, pages 203–212, September 2012
How to Cite
QI, Q. and HU, F. B. (2012), Genetics of type 2 diabetes in European populations. Journal of Diabetes, 4: 203–212. doi: 10.1111/j.1753-0407.2012.00224.x
- Issue published online: 17 AUG 2012
- Article first published online: 17 AUG 2012
- Accepted manuscript online: 10 JUL 2012 11:13AM EST
- Received: 31 May 2012; accepted: 2 July 2012.
- genome-wide association studies;
- type 2 diabetes
Type 2 diabetes (T2D) has become a leading health problem throughout the world. It is caused by environmental and genetic factors, as well as interactions between the two. However, until very recently, the T2D susceptibility genes have been poorly understood. During the past 5 years, with the advent of genome-wide association studies (GWAS), a total of 58 T2D susceptibility loci have been associated with T2D risk at a genome-wide significance level (P < 5 × 10−8), with evidence showing that most of these genetic variants influence pancreatic β-cell function. Most novel T2D susceptibility loci were identified through GWAS in European populations and later confirmed in other ethnic groups. Although the recent discovery of novel T2D susceptibility loci has contributed substantially to our understanding of the pathophysiology of the disease, the clinical utility of these loci in disease prediction and prognosis is limited. More studies using multi-ethnic meta-analysis, gene–environment interaction analysis, sequencing analysis, epigenetic analysis, and functional experiments are needed to identify new susceptibility T2D loci and causal variants, and to establish biological mechanisms.