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Keywords:

  • vitamin C;
  • ascorbic acid;
  • adenocarcinoma;
  • colorectal cancer;
  • cancer;
  • chemotherapy;
  • bladder cancer;
  • N-butyl-N-(4-hydroxybutyl)nitrosamine;
  • tumor initiation;
  • tumor promotion;
  • ascorbate;
  • dehydroascorbate

A prospective, double-blind randomized trial of 10 g ascorbic acid given daily to patients with advanced adenocarcinoma of the colon and rectum, not previously treated by chemotherapy, showed no increased survival.