• 1
    Ministerio de Salud de Chile. Estadisticas de mortalidad y natalidad, Chile. 2000. http:epi.minsal.clepihtmlframesframelhtm. March 2003.
  • 2
    Nazer J, Lopez-Camelo J, Castilla E. ECLAMC: results of thirty years of epidemiological surveillance of neural tube defects. Rev Med Chile. 2001;129: 531539.
  • 3
    Czeizel AE, Dudas I. Prevention of the first occurrence of neural tube defects. N Engl J Med. 1992; 327:18321835.
  • 4
    MRC Vitamin Study Research Group. Prevention of neural tube defects. Lancet. 1991;338:131137.
  • 5
    Instituto Nacional de Estadistica (INE), Banco Central, Servicio Nacional del Consumidor. Chile, 1997.
  • 6
    Hertrampf E. Iron fortification in the Americas. Nutr Rev. 2002;60:S22S25.
  • 7
    Castillo C, Atalah E, Benavides X, Urteaga C. Patrones alimentarios en poblacion adulta de la Region metropolitana. Rev Med Chil. 1997;125:283289.
  • 8
    Ministerio de Salud de Chile. Norma tecnica para la fortificacion de la harina de trigo con vitaminas y minerales. Diciembre 1999.
  • 9
    Honein MA, Paulossi LJ, Mathews TJ, Erickson JD, Wong LYC. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA. 2001;285:29812986.
  • 10
    Persad VL, Van den Hof MC, Dube JM, Zimmer, P. Incidence of open neural tube defects in Nova Scotia after folic acid fortification. CMAJ. 2002;167: 241245.
  • 11
    Martin JI, Landen WO Jr, Soliman AG, Eitenmiller RR. Application of a tri-enzyme extraction for total folate determination in foods. J Assoc Off Anal Chem. 1990;73:805808.
  • 12
    Tamura T. Microbiological assay of folates. In: PiccianoMF, StokstadELR, GregoryJFIII, eds. Folic Acid Metabolism in Health and Disease. Contemporary Issues in Clinical Nutrition. New York : WileyLiss; 1990: 121137.
  • 13
    Hertrampf E, Cortes F, Erickson D, et al. Consumption of folic acid-fortified bread is highly effective in improve folate status in women of reproductive age in Chile. J Nutr. 2003;133:31663169.
  • 14
    Hirsch S, de la Maza P, Barrera G, et al. Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B12 deficiency in elderly people. J Nutr. 2002;132: 289291.
  • 15
    Institute of Medicine, Food and Nutrition Board. Folate. Dietary Reference Intakes for Thiamin, Ribo-flavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington , DC : National Academy Press; 1998: 196303.
  • 16
    COMA and Report. Committee on Medical aspects of Food and Nutrition Policy. Folic Acid and the Prevention of Disease. London : The Stationery Office; 2000.
  • 17
    Mills JL, Von Kohorn I, Conley MR, et al. Low vitamin B-12 concentrations in patients without anemia: the effect of folic acid fortification of grain. Am J Clin Nutr. 2003;7:14741477.
  • 18
    Olivares M, Hertrampf E, Capurro MT, Wegner D. Prevalence of anemia in elderly subjects living at home of micronutrient deficiencies and inflammation. Eur J Clin Nutr. 2000;54:834839.
  • 19
    Daly LE, Kirke PN, Molloy A et al. Folate levels and neural tube defects. Implications for prevention. JAMA. 1995;274:1698702.
  • 20
    Daly S, Mills JL, Molloy AM, et al. Minimum effective dose of folic acid for food fortification to prevent neural tube defects. Lancet. 1997;350:16661669.