Is GAD2 on Chromosome 10p12 a Potential Candidate Gene for Morbid Obesity?
Article first published online: 28 JUN 2008
Volume 63, Issue 9, pages 315–319, September 2005
How to Cite
Tiwari, H. K., Bouchard, L., Perusse, L. and Allison, D. B. (2005), Is GAD2 on Chromosome 10p12 a Potential Candidate Gene for Morbid Obesity?. Nutrition Reviews, 63: 315–319. doi: 10.1111/j.1753-4887.2005.tb00147.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- morbid obesity
Morbidly obese individuals represent one of the fastest growing subpopulations of obese individuals. Thus, it is of significant interest to broaden our understanding of the potential genetic causes of this public health concern. A recent study investigated a role of positional candidate gene GAD2 (the gene for glutamic acid decarboxylase) in the development of morbid obesity. This commentary carefully examines the genetic and functional arguments for and against the GAD2 gene as an influential gene for obesity. Also discussed are additional research questions that merit inquiry when further evaluating this genetic variant as a putative contributor to human obesity.