• 1
    Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al. The sequence of the human genome. Science 2001;291:S1304S1351.
  • 2
    Stover PJ. Nutritional genomics. Physiol Genomics 2004;16:S161S165.
  • 3
    Stover PJ, Garza C. Bringing individuality to public health recommendations. J Nutr 2002;132(8 suppl)):S2476SS2480S.
  • 4
    Morohashi M., Winn AE, Borisuk MT, Bolouri H., Doyle J., Kitano H. Robustness as a measure of plausibility in models of biochemical networks. J Theor Biol 2002;216:S19S30.
  • 5
    Greenspan RJ. The flexible genome. Nat Rev Genet 2001;2:S383S387.
  • 6
    Pal C., Papp B., Hurst LD. Genomic function: Rate of evolution and gene dispensability. Nature 2003;421:S496S498.
  • 7
    Giaever G., Chu AM, Ni L., Connelly C., Riles L., Veronneau S., et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 2002;418:S387S391.
  • 8
    Gasch AP, Werner-Washburne M. The genomics of yeast responses to environmental stress and starvation. Funct Integr Genomics 2002;2:S181S192.
  • 9
    Gasch AP, Spellman PT, Kao CM, et al. Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell 2000;11:S4241S4257.
  • 10
    Albert R., Jeong H., Barabasi AL Error and attack tolerance of complex networks. Nature 2000;406:S378S382.
  • 11
    Delhanty JD. Preimplantation genetics: an explanation for poor human fertility Ann Hum Genet 2001;65(part 4):S331S338.
  • 12
    Brent RL, Beckman DA. The contribution of environmental teratogens to embryonic and fetal loss. Clin Obstet Gynecol 1994;37:S646S670.
  • 13
    Edmonds DK, Lindsay KS, Miller JF, Williamson E., Wood PJ. Early embryonic mortality in women. Fertil Steril 1982;38:S447S453.
  • 14
    Edwards RG. Recent scientific and medical advances in assisted human conception. Int J Dev Biol 1997;41:S255S262.
  • 15
    Wilcox AJ, Weinberg CR, O'Connor JF, et al. Incidence of early loss of pregnancy. N Engl J Med 1988;319:S189S194.
  • 16
    Bulletti C., Flamigni C., Giacomucci E. Reproductive failure due to spontaneous abortion and recurrent miscarriage. Hum Reprod Update 1996;2:S118S136.
  • 17
    Brock DJ, Holloway S. Fertility of older women. Lancet 1990;335:S1470.
  • 18
    Cowchock FS, Gibas Z., Jackson LG. Chromosome errors as a cause of spontaneous abortion: the relative importance of maternal age and obstetric history. Fertil Steril 1993;59:S1011S1014.
  • 19
    Gris JC, Perneger TV, Quere I., et al. Antiphospholipid/antiprotein antibodies, hemostasis-related autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case-control study. Blood 2003;102:S3504S3513.
  • 20
    Zetterberg H. Methylenetetrahydrofolate reduc-tase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications. Reprod Biol Endocrinol 2004;2:S7.
  • 21
    Zetterberg H., Regland B., Palmer M., et al. Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos. Eur J Hum Genet 2002;10:S113S118.
  • 22
    Zetterberg H., Regland B., Palmer M., et al. The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion. Hum Reprod 2002;17:S3033S3036.
  • 23
    Zetterberg H., Zafiropoulos A., Spandidos DA, Rymo L., Blennow K. Gene-gene interaction between fetal MTHFR 677C[RIGHTWARDS ARROW]T and transcobalamin 776C[RIGHTWARDS ARROW]G polymorphisms in human spontaneous abortion. Hum Reprod 2003;18:S1948S1950.
  • 24
    Nelen WL, Blom HJ, Steegers EA, den Heijer M., Eskes TK. Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertil Steril 2000;74:S1196S1199.
  • 25
    Nelen WL. Hyperhomocysteinaemia and human reproduction. Clin Chem Lab Med 2001;39:S758S763.
  • 26
    Isotalo PA, Wells GA, Donnelly JG. Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations. Am J Hum Genet 2000;67:S986S990.
  • 27
    Brody LC, Conley M., Cox C., et al. A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetra-hydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: Report of the Birth Defects Research Group. Am J Hum Genet 2002;71:S1207S1215.
  • 28
    Nelen WL, Blom HJ, Steegers EA, den Heijer M., Thomas CM, Eskes TK. Homocysteine and folate levels as risk factors for recurrent early pregnancy loss. Obstet Gynecol 2000;95:S519S524.
  • 29
    Nelen WL, Blom HJ, Thomas CM, Steegers EA, Boers GH, Eskes TK. Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J Nutr 1998;128:S1336S1341.
  • 30
    Akey JM, Eberle MA, Rieder MJ, et al. Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol 2004;2:Se286.
  • 31
    Wooding S. Natural selection: sign, sign, everywhere a sign. Curr Biol 2004;14:SR700SR701.
  • 32
    Wooding S. PopHist: inferring population history from the spectrum of allele frequencies. Bioinformatics 2003;19:S539S540.
  • 33
    Jorde LB, Watkins WS, Bamshad MJ, et al. The distribution of human genetic diversity: a comparison of mitochondrial, autosomal, and Y-chromosome data. Am J Hum Genet 2000;66:S979S988.
  • 34
    Jorde LB, Wooding SP. Genetic variation, classification and “race.” Nat Genet 2004;36(11 suppl):S28S33.
  • 35
    Clark AG, Glanowski S., Nielsen R., et al. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science 2003;302:S1960S1963.
  • 36
    Bamshad M., Wooding SP. Signatures of natural selection in the human genome. Nat Rev Genet 2003;4:S99S111.
  • 37
    Akey JM, Zhang G., Zhang K., Jin L., Shriver MD. Interrogating a high-density SNP map for signatures of natural selection. Genome Res 2002;12:S1805S1814.
  • 38
    Poulter M., Hollox E., Harvey CB, et al. The causal element for the lactase persistence/non-persistence polymorphism is located in a 1 Mb region of linkage disequilibrium in Europeans. Ann Hum Genet 2003;67:S298S311.
  • 39
    Enattah NS, Sahi T., Savilahti E., Terwilliger JD, Peltonen L., Jarvela I. Identification of a variant associated with adult-type hypolactasia. Nat Genet 2002;30:S233S237.
  • 40
    Bersaglieri T., Sabeti PC, Patterson N., et al. Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet 2004;74:S1111S1120.
  • 41
    Toomajian C., Ajioka RS, Jorde LB, Kushner JP, Kreitman M. A method for detecting recent selection in the human genome from allele age estimates. Genetics 2003;165:S287S297.
  • 42
    Toomajian C., Kreitman M. Sequence variation and haplotype structure at the human HFE locus. Genetics 2002;161:S1609S1623.
  • 43
    Beutler E. Iron absorption in carriers of the C282Y hemochromatosis mutation. Am J Clin Nutr 2004; 80:S799S800.
  • 44
    Osier MV, Pakstis AJ, Soodyall H., et al. A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet 2002;71:S84S99.
  • 45
    Loew M., Boeing H., Sturmer T., Brenner H. Relation among alcohol dehydrogenase 2 polymorphism, alcohol consumption, and levels of gamma-glutamyltransferase. Alcohol 2003;29:S131S135.
  • 46
    Ma J., Stampfer MJ, Giovannucci E., et al. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997;57:S1098S1102.
  • 47
    Bailey LB. Folate, methyl-related nutrients, alcohol, and the MTHFR 677C[RIGHTWARDS ARROW]T polymorphism affect cancer risk: intake recommendations. J Nutr 2003;133:S3748SS3753S.
  • 48
    Guenther BD, Sheppard CA, Tran P., Rozen R., Matthews RG, Ludwig ML. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat Struct Biol 1999;6:S359S365.
  • 49
    Nelson RL, Persky V., Davis F., Becker E. Is hereditary hemochromatosis a balanced polymorphism? An analysis of family size among hemochromatosis heterozygotes. Hepatogastroenterology 2001;48:S523S526.
  • 50
    Neel JV. Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress” Am J Hum Genet 1962;14:S353S362.
  • 51
    Diamond J. The double puzzle of diabetes. Nature 2003;423:S599S602.
  • 52
    Waterland RA, Garza C. Potential mechanisms of metabolic imprinting that lead to chronic disease. Am J Clin Nutr 1999;69:S179S197.
  • 53
    Ruden DM, Garfinkel MD, Sollars VE, Lu X. Wad-dington's widget: Hsp90 and the inheritance of acquired characters. Semin Cell Dev Biol 2003;14:S301S310.
  • 54
    Ruden DM, Xiao L., Garfinkel MD, Lu X. Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer. Hum Mol Genet 2005;14(suppl 1):SR149SR155.
  • 55
    Milton CC, Huynh B., Batterham P., Rutherford SL, Hoffmann AA. Quantitative trait symmetry independent of Hsp90 buffering: distinct modes of genetic canalization and developmental stability. Proc Natl Acad Sci U S A 2003;100:S13396S13401.
  • 56
    Gibson G., Wagner G. Canalization in evolutionary genetics: a stabilizing theory Bioessays 2000;22:S372S380.
  • 57
    Siegal ML, Bergman A. Waddington's canalization revisited: developmental stability and evolution. Proc Natl Acad Sci USA 2002;99:S10528S10532.
  • 58
    Davey Smith, Ebrahim S. Mendelian randomization”: can genetic epidemiology contribute to understanding environmental determinants of disease Int J Epidemiol 2003;32:S1S22.
  • 59
    Rutherford SL. From genotype to phenotype: buffering mechanisms and the storage of genetic information. Bioessays 2000;22:S1095S1105.
  • 60
    Rutherford SL, Lindquist S. Hsp90 as a capacitor formorphological evolution. Nature 1998;396:S336S342.
  • 61
    Queitsch C., Sangster TA, Lindquist S. Hsp90 as a capacitor of phenotypic variation. Nature 2002;417:S618S624.
  • 62
    Stover PJ. Physiology of folate and vitamin B12 in health and disease. Nutr Rev 2004;62(6 part 2): S3S13.
  • 63
    Suh JR, Herbig AK, Stover PJ. New perspectives on folate catabolism. Annu Rev Nutr 2001;21:S255S282.
  • 64
    Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997;94:S3290S3295.
  • 65
    Clarke S., Banfield K. S-adenosylmethionine-dependent methyltransferases. In: CarmelR., JacobsonDW, eds. Homocysteine in Health and Disease. Cambridge , UK : Cambridge University Press; 2001.
  • 66
    Finkelstein JD. Homocysteine: a history in progress. Nutr Rev 2000;58:S193S204.
  • 67
    Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals. Semin Thromb Hemost 2000;26:S219S225.
  • 68
    Choi SW, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr 2000;130:S129S132.
  • 69
    Oyama K., Kawakami K., Maeda K., Ishiguro K., Watanabe G. The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer. Anticancer Res 2004;24:S649S654.
  • 70
    Shelnutt KP, Kauwell GP, Gregory JF, et al. Methylenetetrahydrofolate reductase 677C[RIGHTWARDS ARROW]T polymorphism affects DNA methylation in response to controlled folate intake in young women. J Nutr Biochem 2004;15:S554S560.
  • 71
    Quinlivan EP, Davis SR, Shelnutt KP, et al. Methylenetetrahydrofolate reductase 677C[RIGHTWARDS ARROW]T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides. J Nutr 2005;135:S389S396.
  • 72
    Zanetti KA, Stover PJ. Pyridoxal phosphate inhibits dynamic subunit interchange among serine hy-droxymethyltransferase tetramers. J Biol Chem 2003;278:S10142S10149.
  • 73
    Zingg JM, Jones PA. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis 1997;18:S869S882.
  • 74
    Mason JB, Kim Y. Nutritional strategies in the prevention of colorectal cancer. Curr Gastroenterol Rep 1999;1:S341S353.
  • 75
    Kim M., Trinh BN, Long TI, Oghamian S., Laird PW. Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells. Nucleic Acids Res 2004;32:S5742S5749.
  • 76
    Ingrosso D., Cimmino A., Perna AF, et al. Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet 2003;361:S1693S1699.
  • 77
    Petry CJ, Ong KK, Barratt BJ, et al. Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. BMC Genet 2005;6:S22.
  • 78
    Waterland RA, Jirtle RL Early nutrition, epigenetic changes at transposons and imprinted genes and enhanced susceptibility to adult chronic diseases Nutrition 2004;20:S63S68.
  • 79
    Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 2003;23:S5293S5300.
  • 80
    Waterland RA, Shi X., Lin, JR, Smith CA. Nutritional epigenetics in axin-fused (Axin[fu]) mice: kinky “tales” about mom's diet [abstract]. In: Proceedings of the Federation of American Societies for Experimental Biology Conference. Part I (abstract 161.2); 2005; SA218SA219.
  • 81
    Herbig K., Chiang EP, Lee LR, Hills J., Shane B., Stover PJ. Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J Biol Chem 2002;277:S38381S38389.
  • 82
    Perry C., Sastry R., Nasrallah IM, Stover PJ. Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc: implications for inhibition of DNA replication. J Biol Chem 2005;280:S396S400.
  • 83
    Oppenheim EW, Adelman C., Liu X., Stover PJ. Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis. J Biol Chem 2001;276:S19855S19861.
  • 84
    Girgis S., Nasrallah IM, Suh JR, et al. Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyl-transferase gene. Gene 1998;210:S315S324.
  • 85
    Lim U., Peng K., Shane B., et al. Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. J Nutr 2005;135:S1989S1994.
  • 86
    Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 2001;285:S2981S2986.
  • 87
    Delange FM. Control of iodine deficiency in western and central Europe. Cent Eur J Public Health 2003;11:S120S123.
  • 88
    Centers for Disease Control Prevention (CDC). Alcohol consumption among women who are pregnant or who might become pregnant—United States, 2002. MMWR Morb Mortal Wkly Rep. 2004;53:S1178S1181.
  • 89
    Swanson CA. Iron intake and regulation: implications for iron deficiency and iron overload. Alcohol 2003;30:S99S102.
  • 90
    Mellott TJ, Williams CL, Meck WH, Blusztajn JK. Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. FASEB J 2004;18:S545S547.
  • 91
    Heird WC, Lapillonne A. The role of essential fatty acids in development. Annu Rev Nutr 2005;25:S549S571.
  • 92
    Stillman RJ, Rosenberg MJ, Sachs BP. Smoking and reproduction. Fertil Steril 1986;46:S545S566.
  • 93
    de Rycke M., Liebaers I., Van Steirteghem A. Epigenetic risks related to assisted reproductive technologies: risk analysis and epigenetic inheritance. Hum Reprod 2002;17:S2487S2494.
  • 94
    Sinclair KD, Dunne LD, Maxfield EK, et al. Fetal growth and development following temporary exposure of day 3 ovine embryos to an advanced uterine environment. Reprod Fertil Dev 1998;10:S263S269.
  • 95
    Young LE, Fernandes K., McEvoy TG, et al. Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nat Genet 2001;27:S153S154.
  • 96
    Khosla S., Dean W., Reik W., Feil R. Culture of preimplantation embryos and its long-term effects on gene expression and phenotype. Hum Reprod Update 2001;7:S419S427.
  • 97
    Gao S., Latham KE. Maternal and environmental factors in early cloned embryo development. Cytogenet Genome Res 2004;105:S279S284.
  • 98
    Weaver IC, Cervoni N., Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004;7:S847S854.
  • 99
    Weaver IC, Diorio J., Seckl JR, Szyf M., Meaney MJ. Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Ann N Y Acad Sci 2004;1024:S182S212.
  • 100
    Thomassin H., Flavin M., Espinas ML, Grange T. Glucocorticoid-induced DNA demethylation and gene memory during development. Embo J 2001;20:S1974S1983.
  • 101
    Pennisi E. Evolution of developmental diversity. Evo-devo devotees eye ocular origins and more. Science 2002;296:S1010S1011.
  • 102
    Pasqualetti M., Neun R., Davenne M., Rijli FM. Reti-noic acid rescues inner ear defects in Hoxa1 deficient mice. Nat Genet 2001;29:S34S39.
  • 103
    Zhao R., Russell RG, Wang Y., et al. Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs. J Biol Chem 2001;276:S10224S10228.
  • 104
    Finnell RH, Spiegelstein O., Wlodarczyk B., et al. DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation. J Nutr 2002;132(8 suppl)):S2457SS2461S.
  • 105
    Munoz-Moran E., Dieguez-Lucena JL, Fernandez-Arcas N., Peran-Mesa S., Reyes-Engel A. Genetic selection and folate intake during pregnancy. Lancet 1998;352:S1120S1121.
  • 106
    Reyes-Engel A., Munoz E., Gaitan MJ, et al. Implications on human fertility of the 677C[RIGHTWARDS ARROW]T and 1298A3C polymorphisms of the MTHFR gene: consequences of a possible genetic selection. Mol Hum Reprod 2002;8:S952S957.
  • 107
    Whitehead AS. Changes in MTHFR genotype frequencies over time. Lancet 1998;352:S1784S1785.
  • 108
    Bailey LB, Gregory JF Folate metabolism and requirements. J Nutr 1999;129:S779S782.
  • 109
    von Linsingen R., Bompeixe EP, Bicalho Mda G. A case-control study in IL6 and TGFB1 gene polymorphisms and recurrent spontaneous abortion in southern Brazilian patients. Am J Reprod Immunol 2005;53:S94S99.
  • 110
    Prigoshin N., Tambutti M., Larriba J., Gogorza S., Testa R. Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause. Am J Reprod Immunol 2004;52:S36S41.
  • 111
    Daher S., Shulzhenko N., Morgun A., et al. Associations between cytokine gene polymorphisms and recurrent pregnancy loss. J Reprod Immunol 2003;58:S69S77.
  • 112
    Perni SC, Vardhana S., Tuttle SL, Kalish RB, Chasen ST, Witkin SS. Fetal interleukin-1 receptor antagonist gene polymorphism, intra-amniotic interleukin-1 beta levels, and history of spontaneous abortion. Am J Obstet Gynecol 2004;191:S1318S1323.
  • 113
    Sata F., Yamada H., Yamada A., et al. A polymorphism in the CYP17 gene relates to the risk of recurrent pregnancy loss. Mol Hum Reprod 2003;9:S725S728.
  • 114
    Suryanarayana V., Deenadayal M., Singh L. Association of CYP1A1 gene polymorphism with recurrent pregnancy loss in the South Indian population. Hum Reprod 2004;19:S2648S2652.
  • 115
    Schweikert A., Rau T., Berkholz A., Allera A., Daufeldt S., Wildt L. Association of progesterone receptor polymorphism with recurrent abortions. Eur J Obstet Gynecol Reprod Biol 2004;113:S67S72.
  • 116
    Sata F., Yamada H., Kondo T., et al. Glutathione S-transferase M1 and T1 polymorphisms and the risk of recurrent pregnancy loss. Mol Hum Reprod 2003;9:S165S169.
  • 117
    Finan RR, Tamim H., Ameen G., Sharida HE, Rashid M., Almawi WY. Prevalence of factor V G1691A (factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population. Am J Hematol 2002;71:S300S305.
  • 118
    Tempfer C., Unfried G., Zeillinger R., Hefler L., Nagele F., Huber JC. Endothelial nitric oxide synthase gene polymorphism in women with idiopathic recurrent miscarriage. Hum Reprod 2001;16:S1644S1647.
  • 119
    Gloria-Bottini F., Lucarini N., Palmarino R., et al. Phosphoglucomutase genetic polymorphism of newborns. Am J Hum Biol 2001;13:S9S14.