Vitamin A: Is It a Risk Factor for Osteoporosis and Bone Fracture?
Version of Record online: 28 JUN 2008
Volume 65, Issue 10, pages 425–438, October 2007
How to Cite
Ribaya-Mercado, J. D. and Blumberg, J. B. (2007), Vitamin A: Is It a Risk Factor for Osteoporosis and Bone Fracture?. Nutrition Reviews, 65: 425–438. doi: 10.1111/j.1753-4887.2007.tb00268.x
- Issue online: 28 JUN 2008
- Version of Record online: 28 JUN 2008
- vitamin A;
Results from observational studies of the association between vitamin A intake or serum concentration and bone mineral density or fracture are mixed. The inconsistencies may be due, in part, to difficulties in obtaining an accurate assessment of vitamin A intake or status. Serum retinol is a poor measure of vitamin A status because it is subject to homeostatic control. Stable-isotope-dilution methodology gives a validated assessment of the total-body and liver vitamin A stores and is recommended in future studies on vitamin A status and osteoporosis. The potential for exacerbating an already serious public health problem with intakes of vitamin A currently considered safe indicates further research into this matter is warranted.