• 1
    Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 2004;52:8085.
  • 2
    Ray NF, Chan JK, Thamer M, Melton LJ, 3rd. Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Miner Res 1997;12:2435.
  • 3
    Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998;147:755763.
  • 4
    Hamada K, Vannier E, Sacheck JM, Witsell AL, Roubenoff R. Senescence of human skeletal muscle impairs the local inflammatory cytokine response to acute eccentric exercise. Faseb J 2005;19:264266.
  • 5
    Marcell TJ. Sarcopenia: causes, consequences, and preventions. J Gerontol A Biol Sci Med Sci 2003;58:M911916.
  • 6
    Roubenoff R. Catabolism of aging: is it an inflammatory process Curr Opin Clin Nutr Metab Care 2003;6:295299.
  • 7
    Argiles JM, Busquets S, Felipe A, Lopez-Soriano FJ. Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia. Int J Biochem Cell Biol 2005;37:10841104.
  • 8
    Crepaldi G, Maggi S. Sarcopenia and osteoporosis: A hazardous duet. J Endocrinol Invest 2005;28(suppl):6668.
  • 9
    Tidball JG. Interactions between muscle and the immune system during modified musculoskeletal loading. Clin Orthop Relat Res 2002;403(suppl): 100109.
  • 10
    Ling PR, Schwartz JH, Jeevanandam M, Gauldie J, Bistrian BR. Metabolic changes in rats during a continuous infusion of recombinant interleukin-1. Am J Physiol Endocrinol Metab 1996;270:e305312.
  • 11
    Reid MB, Li YP. Tumor necrosis factor-alpha and muscle wasting: a cellular perspective. Respir Res 2001;2:269272.
  • 12
    Taylor WE, Bhasin S, Artaza J, et al. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. Am J Physiol Endocrinol Metab 2001;280:e221228.
  • 13
    Chang HR, Bistrian B. The role of cytokines in the catabolic consequences of infection and injury. J Parenter Enteral Nutr 1998;22:156166.
  • 14
    Quinn LS, Haugk KL, Grabstein KH. Interleukin-15: a novel anabolic cytokine for skeletal muscle. Endocrinology 1995;136:36693672.
  • 15
    Florini JR, Ewton DZ, Coolican SA. Growth hormone and the insulin-like growth factor system in myo-genesis. Endocr Rev 1996;17:481517.
  • 16
    Lang CH, Silvis C, Deshpande N, Nystrom G, Frost RA. Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1 beta, -6, and high-mobility-group pro-tein-1 in skeletal muscle. Shock 2003;19:538546.
  • 17
    Nagaraju K, Raben N, Merritt G, Loeffler L, Kirk K, Plotz P. A variety of cytokines and immunologically relevant surface molecules are expressed by normal human skeletal muscle cells under proinflammatory stimuli. Clin Exp Immunol 1998;113:407414.
  • 18
    Steensberg A, Keller C, Starkie RL, Osada T, Feb-braio MA, Pedersen BK. IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. Am J Physiol Endocrinol Metab 2002;283:e12721278.
  • 19
    Wiendl H, Hohlfeld R, Kieseier BC. Muscle-derived positive and negative regulators of the immune response. Curr Opin Rheumatol 2005;17:714719.
  • 20
    Plomgaard P, Penkowa M, Pedersen BK. Fiber type specific expression of TNF-alpha, IL-6 and IL-18 in human skeletal muscles. Exerc Immunol Rev 2005;11:5363.
  • 21
    Demoule A, Divangahi M, Danialou G, et al. Expression and regulation of CC class chemokines in the dystrophic (mdx) diaphragm. Am J Respir Cell Mol Biol 2005;33:178185.
  • 22
    Cannon JG. Intrinsic and extrinsic factors in muscle aging. Ann NY Acad Sci 1998;854:7277.
  • 23
    Roubenoff R, Harris TB, Abad LW, Wilson PW, Dallal GE, Dinarello CA. Monocyte cytokine production in an elderly population: effect of age and inflammation. J Gerontol A Biol Sci Med Sci 1998;53:M2026.
  • 24
    Harris TB, Kiel D, Roubenoff R, et al. Association of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old: the Framingham Heart Study. J Am Geriatr Soc 1997;45:133139.
  • 25
    Payette H, Roubenoff R, Jacques PF, et al. Insulin-like growth factor-1 and interleukin 6 predict sar-copenia in very old community-living men and women: the Framingham Heart Study. J Am Geriatr Soc 2003;51:12371243.
  • 26
    Roubenoff R, Parise H, Payette HA, et al. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med 2003;115:429435.
  • 27
    Geffken DF, Cushman M, Burke GL, Polak JF, Sak-kinen PA, Tracy RP. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol 2001;153:242250.
  • 28
    Ford ES. Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology 2002;13:561568.
  • 29
    Taaffe DR, Harris TB, Ferrucci L, Rowe J, Seeman TE. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 2000;55:M709715.
  • 30
    Mora S, Lee IM, Buring JE, Ridker PM. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA 2006;295:14121419.
  • 31
    Fischer CP, Berntsen A, Perstrup LB, Eskildsen P, Pedersen BK. Plasma levels of interleukin-6 and C-reactive protein are associated with physical inactivity independent of obesity. Scand J Med Sci Sports 2006.
  • 32
    Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995;95:24092415.
  • 33
    Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:8791.
  • 34
    Colbert LH, Visser M, Simonsick EM, et al. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2004;52:10981104.
  • 35
    Sacheck JM, Cannon JG, Hamada K, Vannier E, Blumberg JB, Roubenoff R. Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress. Am J Physiol Endocrinol Metab 2006;291:e340349.
  • 36
    Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ, Roubenoff R. Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol 2000;88:13211326.
  • 37
    Frontera WR, Meredith CN, O'Reilly KP, Knuttgen HG, Evans WJ. Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol 1988;64:10381044.
  • 38
    Rogers MA, Hagberg JM, Martin WH, 3rd, Ehsani AA, Holloszy JO. Decline in VO2max with aging in master athletes and sedentary men. J Appl Physiol 1990;68:21952199.
  • 39
    Pollock ML, Mengelkoch LJ, Graves JE, et al. Twenty-year follow-up of aerobic power and body composition of older track athletes. J Appl Physiol 1997;82:15081516.