Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases

  1. Mitchell D Knutson1,*,
  2. Christiaan Leeuwenburgh2

Article first published online: 25 SEP 2008

DOI: 10.1111/j.1753-4887.2008.00109.x

Issue

Nutrition Reviews

Nutrition Reviews

Volume 66, Issue 10, pages 591–596, October 2008

Additional Information

How to Cite

Knutson, M. D. and Leeuwenburgh, C. (2008), Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutrition Reviews, 66: 591–596. doi: 10.1111/j.1753-4887.2008.00109.x

Author Information

  1. 1

    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, USA.

  2. 2

    Department of Aging and Geriatrics, College of Medicine, University of Florida, Gainesville, Florida, USA.

*MD Knutson, Food Science and Human Nutrition Department, PO Box 110370, University of Florida, Gainesville, FL, USA. E-mail: mdknutson@ifas.ufl.edu, Phone: +1-352-392-1991 ext. 204; Fax: +1-352-392-9467.

Publication History

  1. Issue published online: 25 SEP 2008
  2. Article first published online: 25 SEP 2008

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Keywords:

  • life span;
  • polyphenol;
  • red wine;
  • sirtuin

Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activity of several transcriptional factors and enzymes responsive to nutrient availability. However, few foods contain resveratrol and humans metabolize it extensively, resulting in very low systemic bioavailability. Substantial research effort now focuses on identifying and testing more bioavailable and potent activators of SIRT1 for use as pharmacologic interventions in aging and age-related disorders.

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