Get access

Vitamin D and tuberculosis

Authors

  • Patricia Chocano-Bedoya,

    1. Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, USA.
    Search for more papers by this author
  • Alayne G Ronnenberg

    Corresponding author
    1. Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, USA.
    Search for more papers by this author

AG Ronnenberg, Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, 209 Chenoweth Lab, 100 Holdsworth Way, Amherst, MA 01003, USA. E-mail: alayne.ronnenberg@gmail.com, Phone: +1-413-545-1076, Fax: +1-413-545-1074.

Abstract

Tuberculosis is highly prevalent worldwide, accounting for nearly two million deaths annually. Vitamin D influences the immune response to tuberculosis, and vitamin D deficiency has been associated with increased tuberculosis risk in different populations. Genetic variability may influence host susceptibility to developing active tuberculosis and treatment response. Studies examining the association between genetic polymorphisms, particularly the gene coding for the vitamin D receptor (VDR), and TB susceptibility and treatment response are inconclusive. However, sufficient evidence is available to warrant larger epidemiologic studies that should aim to identify possible interactions between VDR polymorphisms and vitamin D status.

Ancillary