Modulation of natural immunity in the gut by Escherichia coli strain Nissle 1917

Authors

  • Ilja Trebichavsky,

    1. Division of Immunology and Gnotobiology, Institute of Microbiology at the Academy of Sciences of the Czech Republic, Novy Hradek, Czech Republic
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  • Igor Splichal,

    1. Division of Immunology and Gnotobiology, Institute of Microbiology at the Academy of Sciences of the Czech Republic, Novy Hradek, Czech Republic
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  • Vojtech Rada,

    1. Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources at the Czech University of Life Sciences Prague, Prague, Czech Republic
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  • Alla Splichalova

    Corresponding author
    1. Division of Immunology and Gnotobiology, Institute of Microbiology at the Academy of Sciences of the Czech Republic, Novy Hradek, Czech Republic
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A Splichalova, Institute of Microbiology, AS CR, Doly 183, 549 22 Novy Hradek, Czech Republic. E-mail: splichal@biomed.cas.cz, Phone: +420-491-418-538, Fax: +420-491-478-264.

Abstract

The beneficial effect of probiotic Escherichia coli strain Nissle 1917 (EcN) suggests the gut epithelium plays a basic role in immune interactions with bacteria. Contrary to other commensal strains of Escherichia coli, EcN profoundly modulates the gut barrier to elevate its resistance to microbial pathogens. The present review documents the properties of EcN that have led to the protection of gnotobiotic pigs against lethal enteric infections. This effect could be important in light of the growing number of acquired deficiencies that paralyze gut immunity in humans.

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