Appendix S1. Amplification on certain of the points discussed in the paper “Evidence-Based Criteria in the Nutritional Context”, by Blumberg et al. [Nutr Rev 2010;68(8):478–484].

Figure S1. Plateau diagrams illustrating the difference in measurable response for studies in which the low intake contrast group falls above or below the plateau intake. As Fig. A1A depicts, at least one of the contrast intakes must be below the response plateau if a measurable effect is to be produced. With both intakes at an above the threshold of the plateau (i.e, A1B), response would be expected to be minimal or absent entirely. (Copyright Robert P. Heaney, 2008. Used with permission.)

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