• 1
    Barker DJ. Fetal programming of coronary heart disease. Trends Endocrinol Metab. 2002;13:364368.
  • 2
    Barker DJ. Adult consequences of fetal growth restriction. Clin Obstet Gynecol. 2006;49:270283.
  • 3
    Bavdekar A, Yajnik CS, Fall CH, et al. Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both? Diabetes. 1999;48:24222429.
  • 4
    Veening MA, Van Weissenbruch MM, Delemarre-Van De Waal HA. Glucose tolerance, insulin sensitivity, and insulin secretion in children born small for gestational age. J Clin Endocrinol Metab. 2002;87:46574661.
  • 5
    Barker DJ, Hales CN, Fall CH, et al. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia. 1993;36:6267.
  • 6
    Barker DJ, Martyn CN, Osmond C, et al. Growth in utero and serum cholesterol concentrations in adult life. BMJ. 1993;307:15241527.
  • 7
    Barker DJ, Osmond C, Golding J, et al. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989;298:564567.
  • 8
    Williams S, St George IM, Silva PA. Intrauterine growth retardation and blood pressure at age seven and eighteen. J Clin Epidemiol. 1992;45:12571263.
  • 9
    Clark PM, Hindmarsh PC, Shiell AW, et al. Size at birth and adrenocortical function in childhood. Clin Endocrinol (Oxf). 1996;45:721726.
  • 10
    Matthews SG. Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endocrinol Metab. 2002;13:373380.
  • 11
    Phillips DI, Jones A. Fetal programming of autonomic and HPA function: do people who were small babies have enhanced stress responses? J Physiol. 2006;572(Pt 1):4550.
  • 12
    Matthews SG, Challis JR. Regulation of the hypothalamo-pituitary-adrenocortical axis in fetal sheep. Trends Endocrinol Metab. 1996;7:239246.
  • 13
    Kahn HS, Graff M, Stein AD, et al. A fingerprint marker from early gestation associated with diabetes in middle age: the Dutch Hunger Winter Families Study. Int J Epidemiol. 2009;38:101109.
  • 14
    Heijmans BT, Tobi EW, Stein AD, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A. 2008;105:1704617049.
  • 15
    Öberg S, Cnattingius S, Sandin S, et al. Birth weight predicts risk of cardiovascular disease within dizygotic but not monozygotic twin pairs: a large population-based co-twin control study. Circulation. 2011;123:27922798.
  • 16
    Palinski W. It takes three to tango: genes complicate the association between birth weight and cardiovascular disease. Circulation. 2011;123:27732775.
  • 17
    Guerrant RL, Oria RB, Moore SR, et al. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr Rev. 2008;66:487505.
  • 18
    Lunn PG. The impact of infection and nutrition on gut function and growth in childhood. Proc Nutr Soc. 2000;59:147154.
  • 19
    Sawaya AL, Martins PA, Baccin Martins VJ, et al. Malnutrition, long-term health and the effect of nutritional recovery. Nestle Nutr Workshop Ser Pediatr Program. 2009;63:95108.
  • 20
    Checkley W, Buckley G, Gilman RH, et al. Multi-country analysis of the effects of diarrhoea on childhood stunting. Int J Epidemiol. 2008;37:816830.
  • 21
    Victora CG, Adair L, Fall C, et al. Maternal and child undernutrition: consequences for adult health and human capital. Lancet. 2008;371:340357.
  • 22
    Godfrey KM, Gluckman PD, Hanson MA. Developmental origins of metabolic disease: life course and intergenerational perspectives. Trends Endocrinol Metab. 2011;21:199205.
  • 23
    Lieb DC, Snow RE, DeBoer MD. Socioeconomic factors in the development of childhood obesity and diabetes. Clin Sports Med. 2009;28:349378.
  • 24
    McKay S, Gaudier E, Campbell DI, et al. Environmental enteropathy: new targets for nutritional interventions. Int Health. 2010;2:172180.
  • 25
    Levine MM. Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine. BMC Biol. 2010;8:129.
  • 26
    Guerrant RL, Schorling JB, McAuliffe JF, et al. Diarrhea as a cause and an effect of malnutrition: diarrhea prevents catch-up growth and malnutrition increases diarrhea frequency and duration. Am J Trop Med Hyg. 1992;47(Pt 2):2835.
  • 27
    Moore SR, Lima NL, Soares AM, et al. Prolonged episodes of acute diarrhea reduce growth and increase risk of persistent diarrhea in children. Gastroenterology. 2010;139:11561164.
  • 28
    Schorling JB, McAuliffe JF, de Souza MA, et al. Malnutrition is associated with increased diarrhoea incidence and duration among children in an urban Brazilian slum. Int J Epidemiol. 1990;19:728735.
  • 29
    Moore SR, Lima AA, Conaway MR, et al. Early childhood diarrhoea and helminthiases associate with long-term linear growth faltering. Int J Epidemiol. 2001;30:14571464.
  • 30
    Ruel MT, Rivera J, Habicht JP, et al. Differential response to early nutrition supplementation: long-term effects on height at adolescence. Int J Epidemiol. 1995;24:404412.
  • 31
    Quadro L, Gamble MV, Vogel S, et al. Retinol and retinol-binding protein: gut integrity and circulating immunoglobulins. J Infect Dis. 2000;182(Suppl 1):S97S102.
  • 32
    Alam AN, Sarker SA, Wahed MA, et al. Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation. Gut. 1994;35:17071711.
  • 33
    Campbell DI, Elia M, Lunn PG. Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. J Nutr. 2003;133:13321338.
  • 34
    Goto R, Mascie-Taylor CG, Lunn PG. Impact of intestinal permeability, inflammation status and parasitic infections on infant growth faltering in rural Bangladesh. Br J Nutr. 2009;101:15091516.
  • 35
    Beaton GH, Ghassemi H. Supplementary feeding programs for young children in developing countries. Am J Clin Nutr. 1982;35(Suppl 4):863916.
  • 36
    Brown NK, Thompson DJ, Prentice RL. Nontreatment and aggressive narcotic therapy among hospitalized pancreatic cancer patients. J Am Geriatr Soc. 1998;46:839848.
  • 37
    Martorell R. Results and implications of the INCAP follow-up study. J Nutr. 1995;125(Suppl 4):S1127S1138.
  • 38
    Chen P, Soares AM, Lima AA, et al. Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil. J Health Popul Nutr. 2003;21:309315.
  • 39
    Lima AA, Soares AM, Lima NL, et al. Effects of vitamin A supplementation on intestinal barrier function, growth, total parasitic, and specific Giardia spp infections in Brazilian children: a prospective randomized, double-blind, placebo-controlled trial. J Pediatr Gastroenterol Nutr. 2010;50:309315.
  • 40
    Solomons NW, Mazariegos M, Brown KH, et al. The underprivileged, developing country child: environmental contamination and growth failure revisited. Nutr Rev. 1993;51:327332.
  • 41
    Campbell DI, McPhail G, Lunn PG, et al. Intestinal inflammation measured by fecal neopterin in Gambian children with enteropathy: association with growth failure, Giardia lamblia, and intestinal permeability. J Pediatr Gastroenterol Nutr. 2004;39:153157.
  • 42
    Jafar TH, Qadri Z, Islam M, et al. Rise in childhood obesity with persistently high rates of undernutrition among urban school-aged Indo-Asian children. Arch Dis Child. 2008;93:373378.
  • 43
    Kimani-Murage EW, Kahn K, Pettifor JM, et al. The prevalence of stunting, overweight and obesity, and metabolic disease risk in rural South African children. BMC Public Health. 2010;10:158.
  • 44
    Florencio TM, Ferreira HS, de Franca AP, et al. Obesity and undernutrition in a very-low-income population in the city of Maceio, northeastern Brazil. Br J Nutr. 2001;86:277284.
  • 45
    Walker SP, Wachs TD, Grantham-McGregor S, et al. Inequality in early childhood: risk and protective factors for early child development. Lancet. 2011;378:13251338.
  • 46
    Walker SP, Wachs TD, Gardner JM, et al. Child development: risk factors for adverse outcomes in developing countries. Lancet. 2007;369:145157.
  • 47
    Mitchell J. The long term association of early childhood diarrhea with school success: a case study from Pakistan. J Educ Int Dev. 2006;2:111.
  • 48
    Berkman DS, Lescano AG, Gilman RH, et al. Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study. Lancet. 2002;359:564571.
  • 49
    Black RE, Allen LH, Bhutta ZA, et al. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet. 2008;371:243260.
  • 50
    Guerrant RL, Kosek M, Lima AA, et al. Updating the DALYs for diarrhoeal disease. Trends Parasitol. 2002;18:191193.
  • 51
    Doak CM, Adair LS, Bentley M, et al. The dual burden household and the nutrition transition paradox. Int J Obes (Lond). 2005;29:129136.
  • 52
    Jehn M, Brewis A. Paradoxical malnutrition in mother-child pairs: untangling the phenomenon of over- and under-nutrition in underdeveloped economies. Econ Hum Biol. 2009;7:2835.
  • 53
    Barker DJ, Osmond C, Forsen TJ, et al. Trajectories of growth among children who have coronary events as adults. N Engl J Med. 2005;353:18021809.
  • 54
    Bhargava SK, Sachdev HS, Fall CH, et al. Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N Engl J Med. 2004;350:865875.
  • 55
    Fall CH, Sachdev HS, Osmond C, et al. Adult metabolic syndrome and impaired glucose tolerance are associated with different patterns of BMI gain during infancy: data from the New Delhi Birth Cohort. Diabetes Care. 2008;31:23492356.
  • 56
    Ferreira HS, Moura FA, Cabral CR, Jr., et al. Short stature of mothers from an area endemic for undernutrition is associated with obesity, hypertension and stunted children: a population-based study in the semi-arid region of Alagoas, Northeast Brazil. Br J Nutr. 2009;101:12391245.
  • 57
    Florencio TT, Ferreira HS, Cavalcante JC, et al. Short stature, abdominal obesity, insulin resistance and alterations in lipid profile in very low-income women living in Maceio, north-eastern Brazil. Eur J Cardiovasc Prev Rehabil. 2007;14:346348.
  • 58
    Florencio TT, Ferreira HS, Cavalcante JC, et al. Short stature, obesity and arterial hypertension in a very low income population in North-eastern Brazil. Nutr Metab Cardiovasc Dis. 2004;14:2633.
  • 59
    Sesso R, Barreto GP, Neves J, et al. Malnutrition is associated with increased blood pressure in childhood. Nephron Clin Pract. 2004;97:c61c66.
  • 60
    Grillol LP, Siqueira AF, Silva AC, et al. Lower resting metabolic rate and higher velocity of weight gain in a prospective study of stunted vs nonstunted girls living in the shantytowns of Sao Paulo, Brazil. Eur J Clin Nutr. 2005;59:835842.
  • 61
    Martins PA, Sawaya AL. Evidence for impaired insulin production and higher sensitivity in stunted children living in slums. Br J Nutr. 2006;95:9961001.
  • 62
    Margolis R. The Effects of Early Childhood Diseases on Young Adult Health in Guatemala. Philadelphia, PA: Population Aging Research Center; 2008. PARC Working Paper Series, WPS 08-07:1–30.
  • 63
    Margolis R. Childhood morbidity and health in early adulthood: life course linkages in a high morbidity context. Adv Life Course Res. 2010;15:132146.
  • 64
    Pinney SE, Simmons RA. Epigenetic mechanisms in the development of type 2 diabetes. Trends Endocrinol Metab. 2010;21:223229.
  • 65
    Kappeler L, De Magalhaes Filho C, Leneuve P, et al. Early postnatal nutrition determines somatotropic function in mice. Endocrinology. 2009;150:314323.
  • 66
    Park JH, Stoffers DA, Nicholls RD, et al. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Invest. 2008;118:23162324.
  • 67
    Raychaudhuri N, Raychaudhuri S, Thamotharan M, et al. Histone code modifications repress glucose transporter 4 expression in the intrauterine growth-restricted offspring. J Biol Chem. 2008;283:1361113626.
  • 68
    Tobi EW, Lumey LH, Talens RP, et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet. 2009;18:40464053.
  • 69
    McCall CE, El Gazzar M, Liu T, et al. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol. 2011;90:439446.
  • 70
    Kellermayer R, Dowd SE, Harris RA, et al. Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll-like receptor 2-knockout mice. FASEB J. 2011;25:14491460.
  • 71
    Florencio TT, Ferreira HS, Cavalcante JC, et al. Food consumed does not account for the higher prevalence of obesity among stunted adults in a very-low-income population in the Northeast of Brazil (Maceio, Alagoas). Eur J Clin Nutr. 2003;57:14371446.
  • 72
    Hoffman DJ, Martins PA, Roberts SB, et al. Body fat distribution in stunted compared with normal-height children from the shantytowns of Sao Paulo, Brazil. Nutrition. 2007;23:640646.
  • 73
    Schorling JB, Guerrant RL. Diarrhoea and catch-up growth. Lancet. 1990;335:599600.
  • 74
    Kronenberg HM, Melmed S, Polonsky KS, et al., eds. Williams Textbook of Endocrinology, 11th ed. Philadelphia: Elsevier Health Sciences; 2007.
  • 75
    Krikorian A, Khan M. Is metabolic syndrome a mild form of Cushing's syndrome? Rev Endocr Metab Disord. 2010;11:141145.
  • 76
    McEwen BS, Gianaros PJ. Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease. Ann N Y Acad Sci. 2010;1186:190222.
  • 77
    McGowan PO, Sasaki A, D'Alessio AC, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci. 2009;12:342348.
  • 78
    Meaney MJ, Szyf M, Seckl JR. Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends Mol Med. 2007;13:269277.
  • 79
    Zhang TY, Hellstrom IC, Bagot RC, et al. Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus. J Neurosci. 2010;30:1313013137.
  • 80
    Fernald LC, Grantham-McGregor SM. Stress response in school-age children who have been growth retarded since early childhood. Am J Clin Nutr. 1998;68:691698.
  • 81
    Fernald LC, Grantham-McGregor SM. Growth retardation is associated with changes in the stress response system and behavior in school-aged Jamaican children. J Nutr. 2002;132:36743679.
  • 82
    Fernald LC, Grantham-McGregor SM, Manandhar DS, et al. Salivary cortisol and heart rate in stunted and nonstunted Nepalese school children. Eur J Clin Nutr. 2003;57:14581465.
  • 83
    Chaillou E, Baumont R, Tramu G, et al. Long-term undernutrition followed by short-term refeeding effects on the corticotropin-releasing hormone containing neurones in the paraventricular nucleus: an immunohistochemical study in sheep. J Neuroendocrinol. 2002;14:269275.
  • 84
    Avraham Y, Hao S, Mendelson S, et al. Hypothalamic-pituitary-adrenal responses to weight loss in mice following diet restriction, activity or separation stress: effects of tyrosine. Nutr Neurosci. 2002;5:327335.
  • 85
    Bose M, Olivan B, Laferrere B. Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis in metabolic disease. Curr Opin Endocrinol Diabetes Obes. 2009;16:340346.
  • 86
    Clark WF, Sontrop JM, Macnab JJ, et al. Long term risk for hypertension, renal impairment, and cardiovascular disease after gastroenteritis from drinking water contaminated with Escherichia coli O157:H7: a prospective cohort study. BMJ. 2010;341:c6020.
  • 87
    Nilsson PM. Elevated blood pressure predicts type 2 diabetes, but why? J Hypertens. 2008;26:17401741.
  • 88
    Prentice AM. Early influences on human energy regulation: thrifty genotypes and thrifty phenotypes. Physiol Behav. 2005;86:640645.
  • 89
    Oria RB, Patrick PD, Blackman JA, et al. Role of apolipoprotein E4 in protecting children against early childhood diarrhea outcomes and implications for later development. Med Hypotheses. 2007;68:10991107.
  • 90
    Oria RB, Patrick PD, Zhang H, et al. APOE4 protects the cognitive development in children with heavy diarrhea burdens in Northeast Brazil. Pediatr Res. 2005;57:310316.
  • 91
    Subramanian SV, Ozaltin E, Finlay JE. Height of nations: a socioeconomic analysis of cohort differences and patterns among women in 54 low- to middle-income countries. PLoS ONE. 2011;6:e18962.
  • 92
    Schlaudecker EP, Steinhoff MC, Moore SR. Interactions of diarrhea, pneumonia, and malnutrition in childhood: recent evidence from developing countries. Curr Opin Infect Dis. 2011;24:496502.