C-reactive protein: an independent predictor of cardiovascular disease in Aboriginal Australians
Article first published online: 8 JUL 2010
© 2010 The Authors. Journal Compilation © 2010 Public Health Association of Australia
Australian and New Zealand Journal of Public Health
Volume 34, Issue Supplement s1, pages S25–S29, July 2010
How to Cite
Wang, Z. and Hoy, W. E. (2010), C-reactive protein: an independent predictor of cardiovascular disease in Aboriginal Australians. Australian and New Zealand Journal of Public Health, 34: S25–S29. doi: 10.1111/j.1753-6405.2010.00548.x
- Issue published online: 8 JUL 2010
- Article first published online: 8 JUL 2010
- Submitted: November 2008 Revision requested: November 2009 Accepted: November 2009
- C-reactive protein;
- Cardiovascular disease risk;
Objectives: We assessed the independent contribution of C-reactive protein to the risk of cardiovascular disease in Aboriginal Australians.
Methods: High sensitivity CRP levels were measured in 705 Aboriginal participants aged 20–74 years free from CVD at baseline. Participants were followed for a median of 11 years. Cox proportional hazards models were used to assess the association of CRP with the risk of developing CVD events.
Results: A total of 114 participants were diagnosed with CVD. Incidence rates were 5.4 and 21.4 per 1,000 person-years for the lower (<3 mg/l) and the higher (≥3 mg/l) CRP groups, respectively. After adjusting for age, sex, total cholesterol, systolic blood pressure, smoking status, diabetes, BMI and waist circumference, the association between CRP and CVD remained significant, with a hazard ratio of 2.40 (95% CI: 1.25, 4.62) for the higher CRP group relative to the lower CRP group. The population attributable risk was 52% (95% CI: 14%, 74%).
Conclusions: CRP is an independent predictor of CVD in Aboriginal people. A large proportion of CVD cases are associated with elevated CRP levels. Therefore, controlling the conditions that cause inflammation may be beneficial to cardiovascular health in Aboriginal communities.