The primary federal regulation concerning employment testing has not been revised in over 3 decades. The regulation is substantially inconsistent with scientific knowledge and professional guidelines and practice. We summarize these inconsistencies and outline the problems faced by U.S. employers in complying with the regulations. We describe challenges associated with changing federal regulations and invite commentary as to how such changes can be implemented. We conclude that professional organizations, such as the Society for Industrial and Organizational Psychology (SIOP), should be much more active in promoting science-based federal regulation of employment practices.