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Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein

Authors

  • ZM Fang,

    1. Departments of 1Radiation Oncology and 2Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of NSW, Kogarah, New South Wales,3Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland, Australia; and 4Department of Surgery, Third Affiliated Hospital, Harbin Medical University, Harbin, China
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  • 1, RV Tse,

    1. Departments of 1Radiation Oncology and 2Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of NSW, Kogarah, New South Wales,3Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland, Australia; and 4Department of Surgery, Third Affiliated Hospital, Harbin Medical University, Harbin, China
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  • 1, VM Marjoniemi,

    1. Departments of 1Radiation Oncology and 2Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of NSW, Kogarah, New South Wales,3Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland, Australia; and 4Department of Surgery, Third Affiliated Hospital, Harbin Medical University, Harbin, China
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  • 2 S Kozlov,

    1. Departments of 1Radiation Oncology and 2Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of NSW, Kogarah, New South Wales,3Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland, Australia; and 4Department of Surgery, Third Affiliated Hospital, Harbin Medical University, Harbin, China
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  • 3 MF Lavin,

    1. Departments of 1Radiation Oncology and 2Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of NSW, Kogarah, New South Wales,3Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland, Australia; and 4Department of Surgery, Third Affiliated Hospital, Harbin Medical University, Harbin, China
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  • 3 H Chen,

    1. Departments of 1Radiation Oncology and 2Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of NSW, Kogarah, New South Wales,3Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland, Australia; and 4Department of Surgery, Third Affiliated Hospital, Harbin Medical University, Harbin, China
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  • 4 JH Kearsley,

    1. Departments of 1Radiation Oncology and 2Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of NSW, Kogarah, New South Wales,3Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland, Australia; and 4Department of Surgery, Third Affiliated Hospital, Harbin Medical University, Harbin, China
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  • 1 PH Graham,

    1. Departments of 1Radiation Oncology and 2Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of NSW, Kogarah, New South Wales,3Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland, Australia; and 4Department of Surgery, Third Affiliated Hospital, Harbin Medical University, Harbin, China
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  • and 1 RA Clarke 1

    1. Departments of 1Radiation Oncology and 2Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of NSW, Kogarah, New South Wales,3Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland, Australia; and 4Department of Surgery, Third Affiliated Hospital, Harbin Medical University, Harbin, China
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  • ZM Fang PhD; RV Tse FRANZCR, MBBS; VM Marjoniemi FRCPA; S Kozlov PhD; MF Lavin PhD; H Chen MD; JH Kearsley FRACP; PH Graham FRANZCR, PhD; RA Clarke PhD

  • *

    Zhi Ming Fang and Regina V Tse contributed equally to this work

    Conflicts of interest: None.

Dr Raymond A Clarke, Department of Radiation Oncology, Cancer Care Centre, St George Hospital, Short Street, Kogarah, NSW 2217, Australia.
Email: r.clarke@unsw.edu.au

Summary

Malignant myoepithelioma of the breast (MMB) is a rare and often aggressive disease with poor prognosis. Little is known regarding its optimal treatment and progression. We describe the clinical history of a woman following excision of a benign adenomyoepithelioma which recurred years later as a radioresistant malignant myoepithelioma with high levels of ataxia telangiectasia mutated protein and mutant p53 (Cys135Phe). MMB requires close follow-up and aggressive treatment. If adjuvant radiotherapy is adopted to improve local control, minimal postoperative delay and higher doses than for standard post-mastectomy radiation are recommended.

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