There are few lingering doubts from epidemiological data as well as scientific information regarding the massive risk UVR imposes on development of skin cancer. Skin cancer is the most common malignancy in the US with well over 1 million cases of non melanoma skin cancers as well as over 60,000 cases of malignant melanoma estimated for 2007 (melanoma in situ will account for an additional 46,000 cases) (Dennis, 1999; Moan et al., 2008), with skin cancer accounting for more than 50% of all malignancies (Ibrahim and Brown, 2008). The World Health Organization has estimated that in the year 2000, up to 71,000 deaths worldwide were attributable to excessive UV exposure (WHO, 2006). The incidence of skin cancer continues to rise faster than that of any other cancer, with the lifetime risk for an American to develop melanoma estimated to have increased approximately 2000% in the past 75 years (Dennis, 1999). Although several associations have been established for skin cancer risk, such as skin phototype, immune response, viral infection, and genetic background, nonetheless solar UVR is broadly accepted to be the main initiator and promoter of skin cancer, particularly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) (Gallagher and Lee, 2006). For SCC, the weight of evidence points towards “chronic” or total exposure. Among women under 40, the rate of BCC has tripled in the past 30 years, while that of SCC has quadrupled (Marks et al., 1988). At current rates, 1 in 5 people in the United States will develop a skin cancer of some sort during their lifetime (Levine et al., 2005), with more than 1 million new cases appearing in 2008 alone. The life-time risk in the US of invasive melanoma has increased from 1:1500 in 1935 to 1 in 63 for invasive melanomas and 1 in 33 if in situ melanoma is included, in 2007 (Rigel, 2008). In the USA, melanoma is the most common form of cancer in young adults 25–29 years old (SEER, 2006); and the 2nd most common cancer in adolescents and young adults 15–29 years old (AAD, 2008; SEER, 2006). One American dies from melanoma almost every hour (every 62 minutes) (AAD, 2008). Melanoma incidence has most strongly and consistently been associated with reported ‘‘intermittent sun exposure’’ mostly accrued through recreational activities (Gallagher and Lee, 2006; Walter et al., 1999). Although melanoma accounts for only 5% of total cutaneous malignancy, it is responsible for approximately 75–80% of skin cancer-related deaths (Ibrahim and Brown, 2008; ACS, 2008). Among other factors, risk of skin cancer increases with artificial UV exposure in tanning salons (IARC, 2007), average annual UVR (Armstrong and Kricker, 2001), and latitude, with a direct correlation with BCC and SCC with latitude (Muir et al., 1987; Scotto et al., 1983). A definitive analysis was recently presented, which reviewed multiple studies on indoor tanning use and risk of melanoma as well as non-melanoma skin cancers (IARC, 2007). This study revealed a 75% increased risk of melanoma for individuals who had first use of a tanning bed prior to age 35 as well as a significant increased risk of melanoma in the “ever” vs. “never” indoor tanning group (relative risk (RR), 1.15; confidence interval (CI), 1.00–1.31). The meta-analysis also suggested a significant effect of exposure to indoor tanning appliances for SCC, but not for BCC (RR, 2.25; CI, 1.08–4.70). The risks for BCC and SCC were also noted to be related to age of first use, with the risk increasing by 10% (odds ratio (OR), 1.1; CI, 0.9–1.5) and 20% (OR, 1.2; CI, 0.9–1.6) respectively for each decade younger the person was at first use of indoor tanning equipment. Although the relative risk figures are lower (though still statistically significant) for melanoma as compared to non-melanoma skin cancer risk, there has been a tendency to ignore non-melanoma skin cancer as a deleterious consequence of recreational UVR. This is a dangerous omission because non-melanoma skin cancer (especially SCC) has a clear metastatic propensity, albeit lower than melanoma, and there are thousands of deaths from non-melanoma skin cancer each year in the US (Ibrahim and Brown, 2008).