1755-148X/asset/olbannercenter.gif?v=1&s=72f30e3842b97b67d7bc25d75c3ceea43fce9409)
Inflammation and melanoma metastasis
Article first published online: 8 APR 2009
DOI: 10.1111/j.1755-148X.2009.00570.x
© 2009 John Wiley & Sons A/S
Additional Information
How to Cite
Melnikova, V. O. and Bar-Eli, M. (2009), Inflammation and melanoma metastasis. Pigment Cell & Melanoma Research, 22: 257–267. doi: 10.1111/j.1755-148X.2009.00570.x
Publication History
- Issue published online: 11 MAY 2009
- Article first published online: 8 APR 2009
- PUBLICATION DATA Received 27 March 2009, revised and accepted for publication 30 March 2009
- Abstract
- Article
- References
- Cited By
Keywords:
- platelet-activating factor;
- thrombin receptor;
- PAR1;
- melanoma;
- metastasis;
- tumor;
- microenvironment;
- platelets
Summary
Metastatic melanoma is extremely refractory to existing chemotherapeutic drugs and bioimmune adjuvant therapies, and the life span of patients with metastatic melanoma is often measured in months. Understanding the mechanisms responsible for the development of tumor metastasis is critical for finding successful curative measures. An expending amount of data reveal the importance of inflammatory microenvironment and stroma in cancer initiation and progression, which brings new directions and approaches to cancer treatment. This review will summarize current data on the role of the tumor microenvironment in shaping the metastatic phenotype of melanoma.