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Figure S1. Morphology of the Organ of Corti in albino NMRI (A, C, E) and pigmented YRT2 (B, D, F) mice. (A and B) Actin-labeling of the hair bundles with phalloidin. (C and D) Neurofilament 200 kDa labeling of the afferent fibers (arrows) of the organ of Corti and the synapse region (arrowhead). (E and F) Synaptophysin labeling of presynapses in the inner hair cells and efferent fibers arriving at the inner hair cells (IHC, arrowhead) and outer hair cells (OHC, arrowhead) of the organ of Corti. No significant differences were found between genotypes. Scale bar 100 μm.

Figure S2. Na-K-ATPase expression in the stria vascularis of non-transgenic albino NMRI and transgenic (YRT2 and TyrTH) mice at different times after acoustic insult. Albino NMRI mice at (A) 24 h, (B) 3 days and (C) 1 month and transgenic mice (D–E: TyrTH; F: YRT2) at (D) 24 h; (E) 3 days; (F) 1 month. There were no morphological differences between the genotypes studied. Note the mild Na-K-ATPase expression in sections 24 h after acoustic insult.

Table S1. Interpeak latencies I–II and I–IV in response to click evoked stimuli at 90 dB SPL at two different ages. No statistically significant differences were found in the IPL I–IV (central conduction time) value between the genotypes, suggesting a peripheral hearing loss in the albino NMRI mice.

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