Glabrous skin is skin that is hairless as found on volar surfaces of fingers and toes, palms, soles, lips, labia minora, penis, lower anal canal, and external anus.
Genetic and morphologic features for melanoma classification
Article first published online: 13 OCT 2010
© 2010 John Wiley & Sons A/S
Pigment Cell & Melanoma Research
Volume 23, Issue 6, pages 763–770, December 2010
How to Cite
Broekaert, S. M. C., Roy, R., Okamoto, I., van den Oord, J., Bauer, J., Garbe, C., Barnhill, R. L., Busam, K. J., Cochran, A. J., Cook, M. G., Elder, D. E., McCarthy, S. W., Mihm, M. C., Schadendorf, D., Scolyer, R. A., Spatz, A. and Bastian, B. C. (2010), Genetic and morphologic features for melanoma classification. Pigment Cell & Melanoma Research, 23: 763–770. doi: 10.1111/j.1755-148X.2010.00778.x
- Issue published online: 13 OCT 2010
- Article first published online: 13 OCT 2010
- Accepted manuscript online: 27 SEP 2010 09:52AM EST
- PUBLICATION DATA Received 18 August 2010, revised and accepted for publication 15 September 2010, published online 27 September 2010
Melanoma is comprised of biologically distinct subtypes. The defining clinical, histomorphologic, and molecular features are not fully established. This study sought to validate the association between genetic and histomorphologic features previously described and to determine their reproducibility and association with important clinical variables. Detailed clinical and histomorphologic features of 365 primary cutaneous melanomas were assessed by 11 pathologists and correlated with mutation status of BRAF and NRAS. There was substantial agreement in the quantitative assessment of histomorphologic features showing similar or better interobserver reproducibility than the established World Health Organization classification scheme. We confirmed that melanomas with BRAF mutations showed characteristic morphologic features (P < 0.0001) and metastasized more frequently to regional lymph nodes (P = 0.046). Importantly, melanomas without mutations were a heterogeneous group, with a subset having very similar clinical and morphological features as those with BRAF mutation raising the possibility that they are biologically related. Our study confirms an association between histomorphologic features, mutation status, and pattern of metastasis, providing criteria for a refined melanoma classification aimed at defining biologically homogeneous disease subgroups.