Figure S1. Validation of shRNA sequences targeting human SPARC.

Figure S2. Depletion of SPARC causes a G2/M cell cycle arrest in melanoma cells.

Figure S3. Effect of conditional RNAi-mediated depletion of SPARC on cell number and cell cycle progression.

Figure S4. Modulation of cell cycle regulators by SPARC siRNA treatment.

Figure S5. p53 is required for the G2/M cell cycle arrest induced by SPARC depletion.

Figure S6. Depletion of SPARC does not modulate MITF levels in melanoma cells.

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