These authors contributed equally to this work.
Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis
Article first published online: 6 DEC 2010
© 2010 John Wiley & Sons A/S
Pigment Cell & Melanoma Research
Volume 24, Issue 2, pages 366–376, April 2011
How to Cite
Lam, T.-L., Wong, G. K. Y., Chow, H.-Y., Chong, H.-C., Chow, T.-L., Kwok, S.-Y., Cheng, P. N. M., Wheatley, D. N., Lo, W.-H. and Leung, Y.-C. (2011), Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis. Pigment Cell & Melanoma Research, 24: 366–376. doi: 10.1111/j.1755-148X.2010.00798.x
- Issue published online: 10 MAR 2011
- Article first published online: 6 DEC 2010
- Accepted manuscript online: 28 OCT 2010 07:57AM EST
- PUBLICATION DATA Received 26 July 2010, revised and accepted for publication 23 October 2010, published online 28 October 2010
Figure S1. A375 cells were transfected with expression constructs encoding either GFP alone or a GFP-OTC fusion protein (A and B, respectively). Transfection efficiencies were similar judging by the number of green fluorescent cells observed (right panel). (C) MTT assay showed that GFP-OTC-transfected A375 cells were significantly less sensitive to rhArg-mediated growth inhibition after a 3-day treatment, when compared against overexpression of GFP alone or mock transfection without plasmid (n = 3, data plotted as means ± SEM).
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