These authors contributed equally to the work.
BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site
Article first published online: 10 MAR 2011
© 2011 John Wiley & Sons A/S
Pigment Cell & Melanoma Research
Volume 24, Issue 2, pages 345–351, April 2011
How to Cite
Bauer, J., Büttner, P., Murali, R., Okamoto, I., Kolaitis, N. A., Landi, M. T., Scolyer, R. A. and Bastian, B. C. (2011), BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site. Pigment Cell & Melanoma Research, 24: 345–351. doi: 10.1111/j.1755-148X.2011.00837.x
- Issue published online: 10 MAR 2011
- Article first published online: 10 MAR 2011
- Accepted manuscript online: 16 FEB 2011 10:08PM EST
- PUBLICATION DATA Received 15 December 2010, revised and accepted for publication 14 February 2011, published online 16 February 2011
- solar elastosis;
- ultraviolet exposure
Oncogenic BRAF mutations are more frequent in cutaneous melanoma occurring at sites with little or moderate sun-induced damage than at sites with severe cumulative solar ultraviolet (UV) damage. We studied cutaneous melanomas from geographic regions with different levels of ambient UV radiation to delineate the relative effects of cumulative UV damage, age, and anatomic site on the frequency of BRAF mutations. We show that BRAF-mutated melanomas occur in a younger age group on skin without marked solar elastosis and less frequently affect the head and neck area, compared to melanomas without BRAF mutations. The findings indicate that BRAF-mutated melanomas arise early in life at low cumulative UV doses, whereas melanomas without BRAF mutations require accumulation of high UV doses over time. The effect of anatomic site on the mutation spectrum further suggests regional differences among cutaneous melanocytes.