Coverage on: Kennedy, A.L., Morton, J.P., Manoharan, I., Nelson, D.M., Jamieson, N.B., Pawlikowski, J.S., McBryan, T., Doyle, B., McKay, C., Oien, K.A., Enders, G.H., Zhang, R., Sansom, O.J., Adams, P.D. (2011). Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol. Cell. 42(1), 36–49.
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If you can’t beat me, join me: collaborating oncogenes circumventing senescence and causing cancer
Article first published online: 14 JUL 2011
DOI: 10.1111/j.1755-148X.2011.00883.x
© 2011 John Wiley & Sons A/S
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How to Cite
Possik, P. A. and Peeper, D. S. (2011), If you can’t beat me, join me: collaborating oncogenes circumventing senescence and causing cancer. Pigment Cell & Melanoma Research, 24: 586–587. doi: 10.1111/j.1755-148X.2011.00883.x
Publication History
- Issue published online: 18 AUG 2011
- Article first published online: 14 JUL 2011
- Accepted manuscript online: 1 JUL 2011 11:43PM EST
References
- , , et al. (2005). Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725–730.
- , , et al. (2005). Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353, 2135–2147.
- , , et al. (2006). TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955–968.
- , , , and (2010). The essence of senescence. Genes Dev. 24, 2463–2479.
- (2010). PICS-ure this: prosenescence therapy? Cancer Cell 17, 219–220.
- , , , , and (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602.
- , , , , , and (2007). Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol. Cell 27, 183–196.