Oncogene-induced senescence and melanoma: where do we stand?
Article first published online: 22 NOV 2011
© 2011 John Wiley & Sons A/S
Pigment Cell & Melanoma Research
Volume 24, Issue 6, pages 1107–1111, December 2011
How to Cite
Peeper, D. S. (2011), Oncogene-induced senescence and melanoma: where do we stand?. Pigment Cell & Melanoma Research, 24: 1107–1111. doi: 10.1111/j.1755-148X.2011.00933.x
- Issue published online: 22 NOV 2011
- Article first published online: 22 NOV 2011
- Accepted manuscript online: 22 OCT 2011 01:16AM EST
- PUBLICATION DATA Received 17 October 2011, revised and accepted for publication 19 October 2011, published online 22 October 2011.
- tumor suppression
In recent years, many groups have detected biomarkers of cellular senescence in a plethora of neoplastic lesions, in model systems, and humans. Indeed, we have come to realize that oncogene-induced senescence (OIS) acts as a potent barrier to oncogenic transformation, operating alongside cell death programs. We have begun to uncover some of its underlying principles, but many fundamental questions remain. In this perspective, some of the ‘knowns’ and ‘unknowns’ of OIS are discussed, with a focus on melanomagenesis.