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Melanin Chemistry & Pigmentation (MCP)
NLRP1, a regulator of innate immunity associated with vitiligo
Article first published online: 16 DEC 2011
DOI: 10.1111/j.1755-148X.2011.00942.x
© 2011 John Wiley & Sons A/S
Additional Information
How to Cite
D’Osualdo, A. and Reed, J. C. (2012), NLRP1, a regulator of innate immunity associated with vitiligo. Pigment Cell & Melanoma Research, 25: 5–8. doi: 10.1111/j.1755-148X.2011.00942.x
Publication History
- Issue published online: 16 DEC 2011
- Article first published online: 16 DEC 2011
- Accepted manuscript online: 25 NOV 2011 03:17AM EST
- PUBLICATION DATA Received 22 November 2011, revised and accepted for publication 22 November 2011, published online 25 November 2011
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Keywords:
- NLRP1;
- Vitiligo;
- inflammation;
- apoptosis;
- autocleavage;
- polymorphism
Summary
Some familial forms of the dermatological condition vitiligo have recently been linked to polymorphisms in the innate immunity gene, NLRP1. Here, we review what is currently known about the mechanisms that regulate activation of the NLRP1 protein and the downstream effects of NLRP1 on pathways impacting inflammation and apoptosis. How polymorphic variants of the NLRP1 gene contribute to the pathogenesis of vitiligo remains mysterious, requiring further investigation.