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ORIGINAL ARTICLE
Genetic and molecular characterization of uveal melanoma cell lines
Article first published online: 2 FEB 2012
DOI: 10.1111/j.1755-148X.2012.00971.x
Published 2012. This article is a US Government work and is in the public domain in the USA
Additional Information
How to Cite
Griewank, K. G., Yu, X., Khalili, J., Sozen, M. M., Stempke-Hale, K., Bernatchez, C., Wardell, S., Bastian, B. C. and Woodman, S. E. (2012), Genetic and molecular characterization of uveal melanoma cell lines. Pigment Cell & Melanoma Research, 25: 182–187. doi: 10.1111/j.1755-148X.2012.00971.x
Publication History
- Issue published online: 22 FEB 2012
- Article first published online: 2 FEB 2012
- Accepted manuscript online: 11 JAN 2012 10:54AM EST
- PUBLICATION DATA Received 16 October 2011, revised and accepted for publication 2 January 2012, published online 11 January 2012
Keywords:
- uveal melanoma;
- GNAQ;
- GNA11
Summary
The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community.