Genetic and molecular characterization of uveal melanoma cell lines

Authors

  • K. G. Griewank,

    1.  Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Comprehensive Cancer Center, New York, NY, USA
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  • X. Yu,

    1.  Department of Melanoma Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
    2.  Department of Systems Biology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
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  • J. Khalili,

    1.  Department of Melanoma Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
    2.  Department of Systems Biology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
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  • M. M. Sozen,

    1.  Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Comprehensive Cancer Center, New York, NY, USA
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  • K. Stempke-Hale,

    1.  Department of Systems Biology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
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  • C. Bernatchez,

    1.  Department of Melanoma Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
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  • S. Wardell,

    1.  Department of Melanoma Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
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  • B. C. Bastian,

    1.  Department of Dermatology and Pathology, Comprehensive Cancer Center, University of California, San Francisco, CA, USA
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  • S. E. Woodman

    1.  Department of Melanoma Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
    2.  Department of Systems Biology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
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S. E. Woodman, e-mail: swoodman@mdanderson.org or B. C. Bastian, e-mail: boris.bastian@ucsf.edu

Summary

The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community.

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