Delving into somatic variation in sporadic melanoma
Version of Record online: 13 FEB 2012
Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
Pigment Cell & Melanoma Research
Volume 25, Issue 2, pages 155–170, March 2012
How to Cite
Walia, V., Mu, E. W., Lin, J. C. and Samuels, Y. (2012), Delving into somatic variation in sporadic melanoma. Pigment Cell & Melanoma Research, 25: 155–170. doi: 10.1111/j.1755-148X.2012.00976.x
- Issue online: 22 FEB 2012
- Version of Record online: 13 FEB 2012
- Accepted manuscript online: 19 JAN 2012 09:05PM EST
- PUBLICATION DATA Received 21 November 2011, revised and accepted for publication 12 January 2012, published online 19 January 2012
- somatic mutation;
Melanoma, the most aggressive form of skin cancer, has increased in incidence more rapidly than any other cancer. The completion of the human genome project and advancements in genomics technologies has allowed us to investigate genetic alterations of melanoma at a scale and depth that is unprecedented. Here, we survey the history of the different approaches taken to understand the genomics of melanoma – from early candidate genes, to gene families, to genome-wide studies. The new era of whole-exome and whole-genome sequencing has paved the way for an in-depth understanding of melanoma biology, identification of new therapeutic targets, and development of novel personalized therapies for melanoma.