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Data S1. Methods.

Table S1.MC1R calls including and excluding rare variants determined using the bioinformatic analysis.  Variant calls based only on the nine variants described in (Duffy et  al. 2004) are in italics, variant calls based upon inclusion of information taken from rare variants are in bold.

Table S2.MC1R status and hair colour in the combined dataset.  MC1R is strongly associated with the hair colour phenotype (Pearson’s Chi-squared test <0.0001).

Table S3. MC1R Genotyping method, patient accrual and follow up in each group.

Table S4. Breakdown of the exclusion of cases ineligible for analysis by cohort.

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