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Retinal cone dysfunction of supernormal rod ERG type
Five new cases
Article first published online: 25 JUN 2009
DOI: 10.1111/j.1755-3768.1993.tb04998.x
1993 Institution Acta Ophthalmologica Scandinavica
1755-3768/asset/cover.gif?v=1&s=e887e0e6012bf8fee98a956bd315ee054c10571a "Acta Ophthalmologica")
Additional Information
How to Cite
Rosenberg, T. and Simonsen, S. E. (1993), Retinal cone dysfunction of supernormal rod ERG type. Acta Ophthalmologica, 71: 246–255. doi: 10.1111/j.1755-3768.1993.tb04998.x
Publication History
- Issue published online: 25 JUN 2009
- Article first published online: 25 JUN 2009
- Recieved October 19th, 1992.
- Abstract
- References
- Cited By
Keywords:
- cGMP;
- cone dystrophy;
- cone dysfunction;
- ERG;
- Müller cell;
- oscillatory potential;
- retinal feedback;
- supernormal rod response
Abstract Five patients, not related to each other, showed clinical signs, including electroretinograms, of a retinal dysfunction which mainly affected die cone system, but also involved the rod responses in a peculiar way. ERG b-wave threshold under dark adapted conditions was elevated. In contrast, rod b-wave sensitivity was enhanced with medium to high intensity flash stimulation. Furthermore, all patients had a severe reduction of the oscillatory potentials. The findings are discussed with special emphasis on a hypothetical disturbance in the cyclic guanosine monophosphate metabolism, involving both photoreceptors and cells of the inner plexiform layer responsible for retinal feedback mechanisms.