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Clinical features and follow-up results of pulsating polypoidal choroidal vasculopathy treated with photodynamic therapy

  1. Suk Ho Byeon,
  2. Young Ju Lew,
  3. Sung Chul Lee,
  4. Oh Woong Kwon

Article first published online: 26 JUN 2009

DOI: 10.1111/j.1755-3768.2009.01517.x

Issue

Acta Ophthalmologica

Acta Ophthalmologica

Volume 88, Issue 6, pages 660–668, September 2010

Additional Information

How to Cite

Byeon, S. H., Lew, Y. J., Lee, S. C. and Kwon, O. W. (2010), Clinical features and follow-up results of pulsating polypoidal choroidal vasculopathy treated with photodynamic therapy. Acta Ophthalmologica, 88: 660–668. doi: 10.1111/j.1755-3768.2009.01517.x

Author Information

  1. Department of Ophthalmology, The Institute of Vision Research, College of Medicine, Yonsei University, Seoul, Korea

*Oh Woong Kwon Department of Ophthalmology The Institute of Vision Research College of Medicine, Yonsei University 134 Seodaemun-Gu, Shinchon-dong Seoul 120-752 Korea Tel: + 82 2 2228 3570 Fax: + 82 2 312 0541 Email: owkwon0301@yuhs.ac

Publication History

  1. Issue published online: 27 AUG 2010
  2. Article first published online: 26 JUN 2009
  3. Received on April 4th, 2008. Accepted on November 29th, 2008.

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Keywords:

  • haemorrhage;
  • photodynamic therapy (PDT);
  • polypoidal choroidal vasculopathy (PCV);
  • pulsatile blood flow;
  • pulsation

Acta Ophthalmol. 2010: 88: 660–668

Abstract.

Purpose:  To report on the clinical course of pulsating polypoidal choroidal vasculopathy (PCV) treated with photodynamic therapy (PDT).

Methods:  A total of 63 eyes of 58 consecutive patients diagnosed with PCV, treated with PDT and followed up for at least 6 months were enrolled. Best-corrected visual acuity (BCVA), fluorescein angiography and high-speed indocyanine green angiography (ICGA) using confocal scanning laser ophthalmoscopy (HRA) were performed.

Results:  Of the 63 PCV eyes, 14 eyes (22.2%) of 14 patients were classified as having pulsating PCV. The mean age of pulsating PCV patients was 60.6 ± 7.0 years (48–69 years), which was younger than non-pulsating PCV patients (65.7 years, p = 0.035). The mean follow-up period was 23.9 ± 10.7 months, and PDT was administered 1.6 ± 0.9 times to pulsating PCV patients. The mean logMAR BCVAs were 0.85 ± 0.47 at presentation and 0.71 ± 0.52 at final examination. Extensive haemorrhagic events were more common in pulsating than in non-pulsating PCV patients (57.1% versus 26.5%, p = 0.032). However, the risk of haemorrhage within 3 months of PDT was similar for both pulsating PCV and the remaining patients (14.3% versus 20%, p = 0.723).

Conclusion:  Pulsating PCV showed distinctive features including a relatively younger patient age at presentation, and a haemorrhagic tendency (especially extensive). However, the use of PDT did not directly increase the risk of haemorrhage in pulsating PCV patients.

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