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Increase of vascular endothelial growth factor and interleukin-6 in the aqueous humour of patients with macular oedema and central retinal vein occlusion

  1. Hidetaka Noma1,2,
  2. Hideharu Funatsu1,
  3. Tatsuya Mimura3,
  4. Seiyo Harino4,
  5. Takashi Sone2,
  6. Sadao Hori5

Article first published online: 26 JUN 2009

DOI: 10.1111/j.1755-3768.2009.01524.x

Issue

Acta Ophthalmologica

Acta Ophthalmologica

Volume 88, Issue 6, pages 646–651, September 2010

Additional Information

How to Cite

Noma, H., Funatsu, H., Mimura, T., Harino, S., Sone, T. and Hori, S. (2010), Increase of vascular endothelial growth factor and interleukin-6 in the aqueous humour of patients with macular oedema and central retinal vein occlusion. Acta Ophthalmologica, 88: 646–651. doi: 10.1111/j.1755-3768.2009.01524.x

Author Information

  1. 1

    Department of Ophthalmology, Yachiyo Medical Centre, Tokyo Women’s Medical University, Chiba, Japan

  2. 2

    Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

  3. 3

    Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

  4. 4

    Department of Ophthalmology, Yodogawa Christian Hospital, Osaka, Japan

  5. 5

    Department of Ophthalmology, Tokyo Women’s Medical University, Tokyo, Japan

*Hidetaka Noma MD Department of Ophthalmology Yachiyo Medical Centre Tokyo Women’s Medical University 477-96 Owada-shinden Yachiyo Chiba 276-8524 Japan Tel: + 81 47 450 6000 Fax: + 81 47 458 7047 Email: nomahide@tymc.twmu.ac.jp

Publication History

  1. Issue published online: 27 AUG 2010
  2. Article first published online: 26 JUN 2009
  3. Received on July 10th, 2008. Accepted on November 30th, 2008.

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Keywords:

  • central retinal vein occlusion;
  • interleukin-6;
  • macular oedema;
  • vascular endothelial growth factor

Acta Ophthalmol. 2010: 88: 646–651

Abstract.

Purpose:  This study aimed to investigate whether vascular endothelial growth factor (VEGF) or interleukin-6 (IL-6) influence macular oedema in patients with central retinal vein occlusion (CRVO).

Methods:  Sixteen consecutive patients with unilateral CRVO and macular oedema were studied, along with eight age- and sex-matched patients without ischaemic ocular disease. Retinal ischaemia was evaluated from capillary non-perfusion on fluorescein angiography. Macular oedema was examined by optical coherence tomography. Aqueous humour (AH) samples were obtained during combined pars plana vitrectomy and cataract surgery, and were examined by enzyme-linked immunosorbent assay.

Results:  Aqueous levels of VEGF and IL-6 were significantly elevated in patients compared with controls (p = 0.0142 and p < 0.0001, respectively). Aqueous levels of both molecules were significantly higher in patients with ischaemia than in those without ischaemia (p = 0.0026 and p = 0.0487, respectively). Furthermore, AH levels of VEGF and IL-6 were correlated with the severity of macular oedema (ρ = 0.7265, p = 0.0049, ρ = 0.5324, and p = 0.0392, respectively).

Conclusions:  Both VEGF and IL-6 were elevated in the AH of patients with macular oedema and ischaemic CRVO, suggesting that these molecules may be related to the increase in vascular permeability in such patients.

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