Comparison of higher order aberration profiles between normal and amblyopic eyes in children with idiopathic amblyopia

Authors

  • Gaurav Prakash,

    1. Cornea and Refractive Surgery Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
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  • Namrata Sharma,

    1. Cornea and Refractive Surgery Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
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  • Rohit Saxena,

    1. Strabismus, Amblyopia and Neuro-ophthalmology Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
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  • Vandana Choudhary,

    1. Cornea and Refractive Surgery Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
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  • Vimla Menon,

    1. Strabismus, Amblyopia and Neuro-ophthalmology Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
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  • Jeewan S. Titiyal

    1. Cornea and Refractive Surgery Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
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Gaurav Prakash, MD
Cornea and refractive surgery services
Rajendra Prasad Centre for Ophthalmic Sciences
All India Institute of Medical Sciences
Ansari Nagar
New Delhi 110029
India
Tel: (91 11) 26589817
Fax: (91 11) 26588919
Email: drgauravprakash@gmail.com

Abstract

Aim:  To evaluate the higher order aberrations and resultant bilateral wavefront patterns in paediatric patients with idiopathic amblyopia.

Material and Methods:  In this cross sectional observational trial, seventeen consecutive patients of previously diagnosed idiopathic amblyopia underwent wavefront analysis on Zyoptix platform (Bausch and Lomb, Rochester, NY, USA).

Results:  The mean age was 9 ± 3 years. There was no significant difference in comparison with means for the Zernike coefficients between normal and amblyopic eye. However, interrelation between Zernike coefficients, which is responsible for their interaction leading to difference in visual function, was different between amblyopic and fellow eyes. This was noticed using stepwise regression analysis. Predicting variables and R2 (r squared) values for each Zernike polynomial were calculated. The sets of significantly predicting coefficients were different in mostpatients, with only seven common pairs and 42 dissimilar dependent-predictor sets. Maximum difference in the R-squared values between amblyopic and normal (fellow) eyes was seen with coma-like and trefoil-like aberrations (third order and fifth order terms).

Conclusion:  It seems a strong possibility that a subset of ‘idiopathic’ amblyopia may be associated with loss of symmetry in wavefront patterns of the two eyes.

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