Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration
Version of Record online: 23 NOV 2011
© 2011 The Authors. Acta Ophthalmologica © 2011 Acta Ophthalmologica Scandinavica Foundation
Volume 90, Issue 4, pages 299–309, June 2012
How to Cite
Kinnunen, K., Petrovski, G., Moe, M. C., Berta, A. and Kaarniranta, K. (2012), Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. Acta Ophthalmologica, 90: 299–309. doi: 10.1111/j.1755-3768.2011.02179.x
- Issue online: 28 MAY 2012
- Version of Record online: 23 NOV 2011
- Received on December 9th, 2010. Accepted on April 9th, 2011.
- macular degeneration;
- retinal pigment epithelium
Age-related macular degeneration (AMD) is attributed to a complex interaction of genetic and environmental factors. It is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium (RPE) and Bruch’s membrane, as well as alterations in choroidal capillaries. AMD pathogenesis is strongly associated with chronic oxidative stress and inflammation that ultimately lead to protein damage, aggregation and degeneration of RPE. Specific degenerative findings for AMD are accumulation of intracellular lysosomal lipofuscin and extracellular drusens. In this review, we discuss thoroughly RPE-derived mechanisms in AMD pathology.