Purpose Laser flare photometry is a noninvasive, objective and quantitative method to measure intraocular inflammation.
Methods The reproducibility and accuracy of flare measurements was proven by laboratory tests and by clinical studies showing low inter- and intra-observer variability. Laser flare photometry values correlate with clinical grades of flare based on slit lamp examination. However, this technique provides a wide range of values for each clinical grade and there are overlapping ranges between grades. Besides,it allows the detection of subclinical blood aqueous barrier disruption.
Results Laser flare photometry has many clinical applications : 1-Uveitis Laser flare photometry shows better sensitivity than the slit lamp grading of cells and flare in monitoring anterior chamber inflammation, in both acute and chronic inflammation. It helps to define the inflammatory profiles of various types of anterior and posterior uveitis. It allows the assessement of the response to treatment and the prediction of the disease relapse. Relationships of laser flare photometry with complications permit to determine the prognosis of uveitis. 2-Post-surgical inflammation An objective evaluation of the blood aqueous barrier disruption after different surgical procedures is provided. The effects of different molecules on the post-surgical inflammation can be evaluated and compared. 3-Several other conditions associated with some degree of blood-aqueous barrier disruption such as diabetic retinopathy
Conclusion Laser flare photometry is an objective and precise technique. It should be the gold standard for the assessment of intraocular inflammation.