Prediction of Response to Antidepressants: Is Quantitative EEG (QEEG) an Alternative?


Dan V. Iosifescu, M.D., M.S., Depression Clinical and Research Program, Massachusetts General Hospital, and Harvard Medical School, 50 Staniford Street, Suite 401, Boston, MA 02114, USA.
Tel.: 617-724-7741;
Fax: 617-724-3028;


Selecting the most effective antidepressant for depressed subjects having failed previous treatments is difficult; the rates of success are relatively low. There is a clear need for objective biomarkers which could assist and optimize such treatment selection. We review here the current literature and recent developments on the role of quantitative EEG (QEEG) predictors of treatment outcome in major depressive disorder.