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Dopamine, Morphine, and Nitric Oxide: An Evolutionary Signaling Triad
Article first published online: 13 NOV 2009
DOI: 10.1111/j.1755-5949.2009.00114.x
© 2009 Blackwell Publishing Ltd
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How to Cite
Stefano, G. B. and Kream, R. M. (2010), Dopamine, Morphine, and Nitric Oxide: An Evolutionary Signaling Triad. CNS Neuroscience & Therapeutics, 16: e124–e137. doi: 10.1111/j.1755-5949.2009.00114.x
Publication History
- Issue published online: 6 MAY 2010
- Article first published online: 13 NOV 2009
References
- 1, . De novo biosynthesis of morphine in animal cells: An evidence-based model. Med Sci Monit 2006;12:RA207–RA219.
- 2, . Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review). Int J Mol Med 2007;20:837–841.
- 3, , . Nitric oxide regulation of mitochondrial oxygen consumption I: Cellular physiology. Am J Physiol Cell Physiol 2006;291:C1225–C1231.
- 4, , . The reaction of nitric oxide with copper proteins and the photodissociation of copper-NO complexes. Biochim Biophys Acta 1987;916:38–47.
- 5, , , , , . Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation. Biochem Pharmacol 1999;57:1011–1019.
- 6, , , et al. L-arginine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion. Ann Thorac Surg 1995;60:1275–1281.
- 7, , , , , , . Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. Hypertension 1994;23:1121–1131.
- 8, , . L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J Immunol 1987;138:550–565.
- 9, . Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant. Planta 2001;213:888–897.
- 10, . Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy. J Biol Chem 1994;269:26684–26690.
- 11, . Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy. Phytochemistry 2003;64:177–186.
- 12, . Expression in Escherichia coli and partial characterization of two tyrosine/dopa decarboxylases from opium poppy. Phytochemistry 1995;38:1119–1126.
- 13, , , . Analysis of promoters from tyrosine/dihydroxyphenylalanine decarboxylase and berberine bridge enzyme genes involved in benzylisoquinoline alkaloid biosynthesis in opium poppy. Plant Mol Biol 1999;40:121–131.
- 14, . Isolation and partial characterization of norcoclaurine synthase, the first committed step in benzylisoquinoline biosynthesis, from poppy. Planta 2001;213:898–906.
- 15, . Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants. J Biol Chem 2002;277:33878–33883.
- 16, . Enzymatic formation of (R)-reticuline from 1,2-dehydroreticuline in the opium poppy plant. Tetrahedron Lett 1990;31:4855–4858.
- 17, . S-Adenosyl-L-methionine: 3’-hydroxy-N-methyl-(S)-coclaurine 4’-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway. Phytochemistry 1990;29:3505–3511.
- 18, . Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum. Phytochemistry 1992;32:79–86.
- 19. The biosynthesis of isoquinoline alkaloids. In: PhillipsonJD, RobertsMF, ZenkMH, eds. The Chemistry and Biology of Isoquinoline Alkaloids. Berlin : Springer-Verlag, 1985;213–228.
- 20, . Closure of the oxide bridge in morphine biosynthesis. Tetrahedron Lett 1994;35:3897–3900.
- 21, . Stereospecific reduction of codeinone, the penultimate enzymatic step during morphine biosynthesis in Papaver somniferum. Tetrahedron Lett 1995;36:2449–2452.
- 22, . Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures. Eur J Biochem 1995;233:132–139.
- 23, . The hydroxylation step in the biosynthesis pathway leading from norcoclaurine to reticuline. Phytochemistry 1990;29:3499–3503.
- 24, , , et al. Presence of morphine in rat amygdala: Evidence for the mu3 opiate receptor subtype via nitric oxide release in limbic structures. Med Sci Monit 2004;10:BR433–BR439.
- 25, , , . In vivo and in vitro L-DOPA exposure increases ganglionic morphine levels. Med Sci Monit 2005;11:MS1–MS5.
- 26, , , et al. Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: CYP2D6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling. Med Sci Monit 2005;11:BR397–BR404.
- 27, , , , . Human white blood cells synthesize morphine: CYP2D6 modulation. J Immunol 2005;175:7357–7362.
- 28, , , , . How human neuroblastoma cells make morphine. Proc Natl Acad Sci USA 2005;102:8495–8500.
- 29, . Histoflourescent localization of serotonin and dopamine in the nervous system and gill of Mytilus edulis (Bivalvia). Biol Bull 1975;148:141–156.
- 30, , . Dopaminergic agents: Influence on serotonin in the molluscan nervous system. Science 1976;194:539–541.
- 31. Comparative aspects of opioid-dopamine interaction. Cell Mol Neurobiol 1982;2:167–178.
- 32. Norepinephrine: Presence and interaction with endogenous biogenic amines. In: StefanoGB, ed. Neurobiology of Mytilus edulis. Manchester : Manchester University Press, 1990:93–103.
- 33, , . Biochemistry of biogenic amines. New York : Plenum Press, 1975.
- 34, . Endogenous morphine and related opiates, a new class of chemical messengers. Adv Neuroimmunol 1994;4:57–68.
- 35. Autoimmunovascular regulation: Morphine and anandamide stimulated nitric oxide release. J Neuroimmunol 1998;83:70–76.
- 36, , , , . Basal nitric oxide limits immune, nervous and cardiovascular excitation: Human endothelia express a mu opiate receptor. Prog Neurobiol 2000;60:513–530.
- 37, , , et al. Endogenous morphine. Trends Neuroscie 2000;9:436–442.
- 38, . The biology of deception: The evolution of cognitive coping as a denial-like process. Med Hypotheses 1995;44:311–314.
- 39, . The biology of deception: Emotion and morphine. Med Hypotheses 1995;49:51–54.
- 40, , . Antibodies as a means of isolating and characterizing biologically active substances: Presence of a non-peptide morphine-like compound in the central nervous system. Proc Natl Acad Sci USA 1976;73:2132–2136.
- 41, , . A nonpeptide morphine-like compound: Immunocytochemical localization in the mouse brain. Science 1978;199:447–448.
- 42, , , . Endogenous codeine and morphine are stored in specific brain neurons. Brain Res 1993;627:210–215.
- 43, , . Immunocytochemical localization of endogenous codeine and morphine. Adv Neuroimmunol 1994;4:83–92.
- 44, , , , , . Endogenous morphine levels increase in molluscan neural and immune tissues after physical trauma. Brain Res 1999;835:137–147.
- 45, , . Endogenous morphine and ACTH association in neural tissues. Med Sci Monit 2005;11:MS22–MS30.
- 46, , , , . Presence and formation of codeine and morphine in the rat. Proc Natl Acad Sci USA 1986;83:4566–4567.
- 47, . Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes. Proc Natl Acad Sci USA 1988;85:1267–1271.
- 48, , , , , , . Morphine and other opiates from beef brain and adrenal. Proc Natl Acad Sci USA 1985;82:5203–5207.
- 49, , , , . Morphine and codeine from mammalian brain. Proc Natl Acad Sci USA 1986;83:9784–9788.
- 50, , . Synthesis of the skeleton of the morphine molecule by mammalian liver. Nature 1987;330:674–677.
- 51, . Formation of the morphine precursor salutaridine is catalyzed by a cytochrome P-450 enzyme mammalian liver. Tetrahedron Lett 1991;32:3675–3678.
- 52, , , . Purification and characterization of a cytochrome P450 enzyme from pig liver, catalyzing the phenol oxidative coupling of (R)-reticuline to salutaridine, the critical step in morphine biosynthesis. Heterocycles 1995;40:425–440.
- 53, , , , , , . Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain. Neurosci Lett 2000;283:224–226.
- 54, , . Augmentation of alkaloid formation from dopamine by alcohol and acetaldehyde in vitro. J Pharmacol Exp Ther 1970;174:401–412.
- 55, , . Salsolinol, an alkaloid derivative of dopamine formed in vitro during alcohol metabolism. Nature 1970;227:1143–1144.
- 56, , , , . Tetrahydropapaveroline: Formation in vivo and in vitro in rat brain. Life Sci 1974;14:2247–2257.
- 57
- 58, , . Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: Occurrence, metabolism and function in human brains. Neurotoxicology 2004;25:193–204.
- 59, , , et al. Endogenous synthesis of N-methylsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in rat brain during in vivo microdialysis with salsolinol, as demonstrated by gas chromatography-mass spectrometry. J Chromatogr 1992;578:109–115.
- 60, , , , . Endogenous formation of morphine in human cells. Proc Natl Acad Sci USA 2004;101:14091–14096.
- 61, , , , . How human neuroblastoma cells make morphine. Proc Natl Acad Sci USA 2005;102:8495–8500.
- 62, , , , . Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: Nicotine addiction. Cell Mol Neurobiol 2006;26:1037–1045.
- 63, , , , , . Gene expression of cytochrome P450 1B1 and 2D6 in leukocytes in human pregnancy. Pharmacol Toxicol 2003;92:295–299.
- 64, , . Dopamine formation from tyramine by CYP2D6. Biochem Biophys Res Commun 1998;249:838–843.
- 65, , , et al. Alcohol-, nicotine-, and cocaine-evoked release of morphine from invertebrate ganglia: Model system for screening drugs of abuse. Med Sci Monit 2006;12:BR155–BR161.
- 66, , , , , . Cholinergic regulation of endogenous morphine release from lobster nerve cord. Med Sci Monit 2006;12:BR295–BR301.
- 67, , , . Alcohol-, nicotine-, and cocaine-evoked release of morphine from human white blood cells: Substances of abuse actions converge on endogenous morphine release. Med Sci Monit 2006;12:BR350–BR354.
- 68, , , et al. Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: The dopamine-morphine hypothesis. Med Sci Monit 2007;13:RA91–RA102.
- 69, , , et al. Opioid and opiate immunoregulatory processes. Crit Rev Immunol 1996;16:109–144.
- 70, . Opiate antagonism of opioid actions on immunocyte activation and nitric oxide release. Anim Biol 1996;1:11–16.
- 71, , , , , . Endogenous morphine: Opening new doors for the treatment of pain and addiction. Expert Opin Biol Ther 2005;5:893–906.
- 72, , . International union of pharmacology nomenclature in nitric oxide research. Pharmacol Rev 1997;49:137–142.
- 73. Signal transduction mechanisms involving nitric oxide. Biochem Pharmacol 1991;41:485–490.
- 74, , . Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109–142.
- 75, . The L-arginine-nitric oxide pathway. New Eng J Med 1993;329:2002–2012.
- 76. Nitric oxide in the vasculature: Physiology and pathophysiology. Ann N Y Acad Sci 1997;811:60–67.
- 77, , , , , . Opiate, cannabinoid, and eicosanoid signaling converges on common intracellular pathways: Nitric oxide coupling. Prostaglandins Other Lipid Mediat 1999;57:23–34.
- 78, , , . NF-kB, nitric oxide and opiate signaling. Med Hypotheses 1999;54:263–268.
- 79, , , , . Tonal nitric oxide and health: A free radical and a scavenger of free radicals. Med Sci Monit 2002;8:1–4.
- 80
- 81, . Integrative medical therapy: Examination of meditation's therapeutic and global medicinal outcomes via nitric oxide (review). Int J Mol Med 2005;16:621–630.
- 82, , , et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006;12:1269–1277.
- 83, , . Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. Exp Neurol 2004;188:341–350.
- 84, . Critical overview of mitochondrial nitric-oxide synthase. Front Biosci 2006;11:2725–2738.
- 85, , , et al. The modulation of mitochondrial nitric-oxide synthase activity in rat brain development. J Biol Chem 2002;277:42447–42455.
- 86, , , et al. Opiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression. Proc Natl Acad Sci USA 1993;90:11099–11103.
- 87, , . Molecular identification and functional expression of mu3, a novel alternatively spliced variant of the human mu opiate receptor gene. J Immunol 2003;170:5118–5123.
- 88, , , , , , . Persistence of evolutionary memory: Primordial six-transmembrane helical domain mu opiate receptors selectively linked to endogenous morphine signaling. Med Sci Monit 2007;13:SC5–SC6.
- 89, , , , , . A functionally coupled mu3-like opiate receptor/nitric oxide regulatory pathway in human multi-lineage progenitor cells. J Immunol 2007;179:5839–5844.
- 90, , . Roles of CRAC and Cav-like channels in T cells: More than one gatekeeper? Trends Pharmacol Sci 2006;27:360–367.
- 91. Pleasure systems in the brain. In: WartburtonDM, ed. Pleasure: The politics and the reality. New York : Wiley & Sons, 1994;5–14.
- 92
- 93, , , . The placebo effect and relaxation response: Neural processes and their coupling to constitutive nitric oxide. Brain Res: Brain Res Rev 2001;35:1–19.
- 94, , , et al. Acupuncture modulates the limbic system and subcortical gray structures of the human brain: Evidence from fMRI studies in normal subjects. Hum Brain Mapp 2000;9:13–25.
- 95, , , . The role of stress in neurodegenerative diseases and mental disorders. Neuroendocrinol Lett 2002;23:199–208.
- 96, . The functional neuroanatomy of emotion and affective style. Trends Cogn Sci 1999;3:11–21.
- 97. Music medicine: Music in association with harm and healing. Musikphysiol Musikermed 2003;10:213–224.
- 98. Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2001;2:119–128.
- 99, , . Molecular basis of neuropharmacology. Columbus : McGraw-Hill, 2001.
- 100, , , et al. Endogenous morphine modulates acute thermonociception in mice. J Neurochem 2002;80:271–277.
- 101, . Role of the limbic system in dependence on drugs. Ann Med 1998;30:397–405.
- 102
- 103, . The neurobiology of pleasure, reward processes, addiction and their health implications. Neuroendocrinol Lett 2004;25:235–251.
- 104. Ventral tegmental reward system. In: OrelandL, EngelJ, eds. Brain reward systems and abuse. New York : Raven Press, 1987;1–17.
- 105, . Facilitation of sexual behaviors in the male rat associated with intra-VTA injections of opiates. Pharmacol Biochem Behav 1990;35:643–650.
- 106, . Feeding elicited by dynorphin (1–13) microinjections into the ventral tegmental area in rats. Life Sci 1988;43:941–946.
- 107. Pleasure response of human subjects to direct stimulation of the brain. In: HeathRG, ed. The role of pleasure in human behavior. New York : Hoeber, 1964;219–243.
- 108, , , , . A novel view of opiate tolerance. Adv Neuroimmunol 1996;6:265–277.
- 109, . Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci 2003;6:1208–1215.
- 110, , , et al. Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci 2004;24:3344–3354.
- 111, , , , . Amphetamine withdrawal modulates FosB expression in mesolimbic dopaminergic target nuclei: Effects of different schedules of administration. Neuropharmacology 2003;44:926–939.
- 112, . Incentive-sensitization and addiction. Addiction 2001;96:103–114.
- 113. New perspectives on cocaine addiction: Recent findings from animal research. Can J Physiol Pharmacol 1989;67:1158–1167.
- 114, , . Marked inhibition of mesolimbic dopamine release: A common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats. Eur J Pharmacol 1992;221:227–234.
- 115, . A psychomotor stimulant theory of addiction. Psychol Rev 1987;94:469–492.
- 116, . Opioids in the ventral tegmental area facilitate the onset of maternal behavior in the rat. Soc Neurosci Abstr 1992;18:539.
- 117, , , , . Commonalities in the central nervous system's involvement with complementary medical therapies: Limbic morphinergic processes. Med Sci Monit 2004;10:MS6–MS17.
- 118, . The neurobiology of love. Neuroendocrinol Lett 2005;26:175–192.
- 119, , . The role of the amygdala in mediating sexual and emotional behavior via coupled nitric oxide release. Acta Pharmacologica Sinica 2005;26:389–395.
- 120, , . Relaxation: Molecular and physiological significance. Med Sci Monit 2006;12:HY21–HY31.
- 121, . Alcohol, amines, and alkaloids: A possible biochemical basis for alcohol addiction. Science 1970;167:1005–1007.
- 122, , , . Alcohol addiction and tetrahydropapaveroline. Science 1970;169:1104–1106.
- 123, , . Tetrahydropapaveroline: An alkaloid metabolite of dopamine in vitro. J Pharmacol Exp Ther 1970;174:388–400.
- 124. Relationship between 3,4-dihydroxyphenylacetaldehyde levels and tetrahydropapaveroline formation. Alcohol Clin Exp Res 1978;2:127–131.
- 125
- 126. Possible steady-state concentrations of tetrahydroisoquinolines in brain after the consumption of ethanol. Fed Proc 1981;40:2082–2085.
- 127, , , . Ethanol preference in rats: Increased consumption after intraventricular administration of tetrahydropapaveroline. Neuropharmacology 1983;22:563–565.
- 128. Anatomical “circuitry” in the brain mediating alcohol drinking revealed by THP-reactive sites in the limbic system. Alcohol 1990;7:449–459.
- 129, . Effects of tetrahydropapaveroline in the nucleus accumbens and the ventral tegmental area on ethanol preference in the rat. Alcohol 1991;8:87–90.
- 130, . Tetrahydropapaveroline injected in the ventral tegmental area shifts dopamine efflux differentially in the shell and core of nucleus accumbens in high-ethanol-preferring (HEP) rats. Alcohol 1999;18:83–90.
- 131, , , . Effect of ethanol on (R)- and (S)-salsolinol, salsoline, and THP in the nucleus accumbens of AA and ANA rats. Alcohol 1999;18:165–169.
- 132, . Ethanol and tetrahydroisoquinoline alkaloids do not produce narcotic discriminative stimulus effects. Psychopharmacology (Berl) 1983;81:224–227.
- 133, , , , . Alcohol induces formation of morphine precursors in the striatum of rats. Life Sci 1997;60:79–89.
- 134, , , , . A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats. Brain Res Bull 2003;60:59–65.
- 135, , . Tetrahydroisoquinoline alkaloids: Uptake by rat brain homogenates and inhibition of catecholamine uptake. J Pharmacol Exp Ther 1971;179:250–258.
- 136, . Tetrahydroisoquinoline alkaloids: Stimulated secretion from the adrenal medulla. J Pharmacol Exp Ther 1973;184:119–128.
- 137, . A comparison of 6,7-dihydroxytetrahydroisoquinoline, salsolinol and tetrahydropapaveroline as inhibitors of monoamine oxidase within the adrenergic nerve plexus of the isolated mouse atrium. Res Commun Chem Pathol Pharmacol 1976;13:217–224.
- 138
- 139, , . Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain. Neurochem Res 1990;15:705–710.
- 140
- 141. Tetrahydropapaveroline in Parkinson's disease and alcoholism: A look back in honor of Merton Sandler. Neurotoxicology 2004;25:117–120.
- 142. L-dopa and pyridoxal 5’-phosphate: Tetrahydroisoquinoline formation. Lancet 1971;297:1068.
- 143, , , . Tetrahydroisoquinoline alkaloids: In vivo metabolites of L-dopa in man. Nature 1973;241:439–443.
- 144
- 145, , , et al. Occurrence of a new class of tetrahydroisoquinoline alkaloids in L-dopa-treated parkinsonian patients. Nature 1977;269:617–619.
- 146, , , , . Increased urinary morphine, codeine and tetrahydropapaveroline in parkinsonian patient undergoing L-3,4-dihydroxyphenylalanine therapy: A possible biosynthetic pathway of morphine from L-3,4-dihydroxyphenylalanine in humans. J Pharmacol Exp Ther 1992;260:974–978.
- 147, , . Tetrahydroisoquinolinecarboxylic acids and catecholamine metabolism in adrenal medulla explants. Biochem Pharmacol 1982;31:3251–3256.
- 148, , , , . Interaction of catecholamine-derived alkaloids with central neurotransmitter receptors. J Neurosci Res 1983;10:175–189.
- 149, , , et al. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells. Neurosci Res 1998;30:87–90.
- 150, , , , , , . Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline. Mutat Res 2003;544:129–142.
- 151, , . Potential roles of NF-kappaB and ERK1/2 in cytoprotection against oxidative cell death induced by tetrahydropapaveroline. Free Radic Biol Med 2004;36:1185–1194.
- 152, , , . Inhibition of dopamine biosynthesis by tetrahydropapaveroline. Neurosci Lett 2005;386:1–4.
- 153, , , et al. Cyclic exercise induces anti-inflammatory signal molecule increases in the plasma of Parkinson's patients. Int J Mol Med 2003;12:485–492.
- 154, . Placebo neural systems: Nitric oxide, morphine and the dopamine brain reward and motivation circuitries. Med Sci Monit 2005;11:MS54–MS65.
- 155, , . Reduction of dyskinesia and induction of akinesia induced by morphine in two parkinsonian patients with severe sciatica. J Neural Transm 1999;106:725–728.
- 156, , , . Morphine in tardive and idiopathic dystonia (short communication). J Neural Transm 2001;108:1035–1041.
- 157, , , . Pain, immunity, opiate and opioid compounds and health. Med Sci Monit 2005;11:MS47–MS53.
- 158, , . Neurobiological implications of eating healthy. Neuro Endocrinol Lett 2006;27:21–33.
- 159, , , . Effect of prolonged exposure to morphine on responsiveness of human and invertebrate immunocytes to stimulatory molecules. J Neuroimmunol 1995;63:175–181.
- 160, , , , , , . Presence of the mu3 opiate receptor in endothelial cells: Coupling to nitric oxide production and vasodilation. J Biol Chem 1995;270:30290–30293.
- 161, , , , , , . Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation. J Biol Chem 1995;270:30290–30293.
- 162, , , et al. Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: Autocrine/paracrine feedback inhibition. Addict Biol 2008;13:118–123.
- 163, , , et al. Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: Implications for cancer biology. Semin Cancer Biol 2008;18:199–210.
- 164

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