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References

  • 1
    Kream RM, Stefano GB. De novo biosynthesis of morphine in animal cells: An evidence-based model. Med Sci Monit 2006;12:RA207RA219.
  • 2
    Stefano GB, Kream RM. Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review). Int J Mol Med 2007;20:837841.
  • 3
    Giulivi C, Kato K, Cooper CE. Nitric oxide regulation of mitochondrial oxygen consumption I: Cellular physiology. Am J Physiol Cell Physiol 2006;291:C1225C1231.
  • 4
    Gorren AC, De Boer E, Wever R. The reaction of nitric oxide with copper proteins and the photodissociation of copper-NO complexes. Biochim Biophys Acta 1987;916:3847.
  • 5
    Madsen L, Garras A, Asins G, Serra D, Hegardt FG, Berge RK. Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation. Biochem Pharmacol 1999;57:10111019.
  • 6
    Engelman DT, Watanabe M, Maulik N, et al. L-arginine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion. Ann Thorac Surg 1995;60:12751281.
  • 7
    Forstermann U, Closs EI, Pollock JS, Nakane M, Schwarz P, Gath I, Kleinert H. Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. Hypertension 1994;23:11211131.
  • 8
    Hibbs JB, Vavrin Z, Taintor RR. L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J Immunol 1987;138:550565.
  • 9
    Bird DA, Facchini PJ. Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant. Planta 2001;213:888897.
  • 10
    Facchini PJ, De LV. Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy. J Biol Chem 1994;269:2668426690.
  • 11
    Facchini PJ, Park SU. Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy. Phytochemistry 2003;64:177186.
  • 12
    Facchini PJ, De LV. Expression in Escherichia coli and partial characterization of two tyrosine/dopa decarboxylases from opium poppy. Phytochemistry 1995;38:11191126.
  • 13
    Park SU, Johnson AG, Penzes-Yost C, Facchini PJ. Analysis of promoters from tyrosine/dihydroxyphenylalanine decarboxylase and berberine bridge enzyme genes involved in benzylisoquinoline alkaloid biosynthesis in opium poppy. Plant Mol Biol 1999;40:121131.
  • 14
    Samanani N, Facchini PJ. Isolation and partial characterization of norcoclaurine synthase, the first committed step in benzylisoquinoline biosynthesis, from poppy. Planta 2001;213:898906.
  • 15
    Samanani N, Facchini PJ. Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants. J Biol Chem 2002;277:3387833883.
  • 16
    De-Eknamkul W, Zenk MH. Enzymatic formation of (R)-reticuline from 1,2-dehydroreticuline in the opium poppy plant. Tetrahedron Lett 1990;31:48554858.
  • 17
    Frenzel T, Zenk MH. S-Adenosyl-L-methionine: 3’-hydroxy-N-methyl-(S)-coclaurine 4’-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway. Phytochemistry 1990;29:35053511.
  • 18
    Gerady R, Zenk MH. Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum. Phytochemistry 1992;32:7986.
  • 19
    Herbert RB. The biosynthesis of isoquinoline alkaloids. In: PhillipsonJD, RobertsMF, ZenkMH, eds. The Chemistry and Biology of Isoquinoline Alkaloids. Berlin : Springer-Verlag, 1985;213228.
  • 20
    Lenz R, Zenk MH. Closure of the oxide bridge in morphine biosynthesis. Tetrahedron Lett 1994;35:38973900.
  • 21
    Lenz R, Zenk MH. Stereospecific reduction of codeinone, the penultimate enzymatic step during morphine biosynthesis in Papaver somniferum. Tetrahedron Lett 1995;36:24492452.
  • 22
    Lenz R, Zenk MH. Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures. Eur J Biochem 1995;233:132139.
  • 23
    Loeffler S, Zenk MH. The hydroxylation step in the biosynthesis pathway leading from norcoclaurine to reticuline. Phytochemistry 1990;29:34993503.
  • 24
    Zhu W, Ma Y, Bell A, et al. Presence of morphine in rat amygdala: Evidence for the mu3 opiate receptor subtype via nitric oxide release in limbic structures. Med Sci Monit 2004;10:BR433BR439.
  • 25
    Zhu W, Mantione KJ, Shen L, Stefano GB. In vivo and in vitro L-DOPA exposure increases ganglionic morphine levels. Med Sci Monit 2005;11:MS1MS5.
  • 26
    Zhu W, Mantione KJ, Shen L, et al. Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: CYP2D6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling. Med Sci Monit 2005;11:BR397BR404.
  • 27
    Zhu W, Cadet P, Baggerman G, Mantione KJ, Stefano GB. Human white blood cells synthesize morphine: CYP2D6 modulation. J Immunol 2005;175:73577362.
  • 28
    Boettcher C, Fellermeier M, Boettcher C, Drager B, Zenk MH. How human neuroblastoma cells make morphine. Proc Natl Acad Sci USA 2005;102:84958500.
  • 29
    Stefano GB, Aiello E. Histoflourescent localization of serotonin and dopamine in the nervous system and gill of Mytilus edulis (Bivalvia). Biol Bull 1975;148:141156.
  • 30
    Stefano GB, Catapane EJ, Aiello E. Dopaminergic agents: Influence on serotonin in the molluscan nervous system. Science 1976;194:539541.
  • 31
    Stefano GB. Comparative aspects of opioid-dopamine interaction. Cell Mol Neurobiol 1982;2:167178.
  • 32
    Stefano GB. Norepinephrine: Presence and interaction with endogenous biogenic amines. In: StefanoGB, ed. Neurobiology of Mytilus edulis. Manchester : Manchester University Press, 1990:93103.
  • 33
    Iversen LL, Iversen SD, Snyder SH. Biochemistry of biogenic amines. New York : Plenum Press, 1975.
  • 34
    Stefano GB, Scharrer B. Endogenous morphine and related opiates, a new class of chemical messengers. Adv Neuroimmunol 1994;4:5768.
  • 35
    Stefano GB. Autoimmunovascular regulation: Morphine and anandamide stimulated nitric oxide release. J Neuroimmunol 1998;83:7076.
  • 36
    Stefano GB, Goumon Y, Bilfinger TV, Welters I, Cadet P. Basal nitric oxide limits immune, nervous and cardiovascular excitation: Human endothelia express a mu opiate receptor. Prog Neurobiol 2000;60:513530.
  • 37
    Stefano GB, Goumon Y, Casares F, et al. Endogenous morphine. Trends Neuroscie 2000;9:436442.
  • 38
    Stefano GB, Fricchione GL. The biology of deception: The evolution of cognitive coping as a denial-like process. Med Hypotheses 1995;44:311314.
  • 39
    Stefano GB, Fricchione GL. The biology of deception: Emotion and morphine. Med Hypotheses 1995;49:5154.
  • 40
    Gintzler AR, Levy A, Spector S. Antibodies as a means of isolating and characterizing biologically active substances: Presence of a non-peptide morphine-like compound in the central nervous system. Proc Natl Acad Sci USA 1976;73:21322136.
  • 41
    Gintzler AR, Gershon MD, Spector S. A nonpeptide morphine-like compound: Immunocytochemical localization in the mouse brain. Science 1978;199:447448.
  • 42
    Bianchi E, Alessandrini C, Guarna M, Tagliamonte A. Endogenous codeine and morphine are stored in specific brain neurons. Brain Res 1993;627:210215.
  • 43
    Bianchi E, Guarna M, Tagliamonte A. Immunocytochemical localization of endogenous codeine and morphine. Adv Neuroimmunol 1994;4:8392.
  • 44
    Sonetti D, Mola L, Casares F, Bianchi E, Guarna M, Stefano GB. Endogenous morphine levels increase in molluscan neural and immune tissues after physical trauma. Brain Res 1999;835:137147.
  • 45
    Sonetti D, Peruzzi E, Stefano GB. Endogenous morphine and ACTH association in neural tissues. Med Sci Monit 2005;11:MS22MS30.
  • 46
    Donnerer J, Oka K, Brossi A, Rice KC, Spector S. Presence and formation of codeine and morphine in the rat. Proc Natl Acad Sci USA 1986;83:45664567.
  • 47
    Kodaira H, Spector S. Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes. Proc Natl Acad Sci USA 1988;85:12671271.
  • 48
    Goldstein A, Barrett RW, James IF, Lowney LI, Weitz C, Knipmeyer LI, Rapoport H. Morphine and other opiates from beef brain and adrenal. Proc Natl Acad Sci USA 1985;82:52035207.
  • 49
    Weitz CJ, Lowney LI, Faull KF, Feistner G, Goldstein A. Morphine and codeine from mammalian brain. Proc Natl Acad Sci USA 1986;83:97849788.
  • 50
    Weitz CJ, Faull KF, Goldstein A. Synthesis of the skeleton of the morphine molecule by mammalian liver. Nature 1987;330:674677.
  • 51
    Amann T, Zenk MH. Formation of the morphine precursor salutaridine is catalyzed by a cytochrome P-450 enzyme mammalian liver. Tetrahedron Lett 1991;32:36753678.
  • 52
    Amann T, Roos PH, Huh H, Zenk MH. Purification and characterization of a cytochrome P450 enzyme from pig liver, catalyzing the phenol oxidative coupling of (R)-reticuline to salutaridine, the critical step in morphine biosynthesis. Heterocycles 1995;40:425440.
  • 53
    Sango K, Maruyama W, Matsubara K, Dostert P, Minami C, Kawai M, Naoi M. Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain. Neurosci Lett 2000;283:224226.
  • 54
    Davis VE, Walsh MJ, Yamanaka Y. Augmentation of alkaloid formation from dopamine by alcohol and acetaldehyde in vitro. J Pharmacol Exp Ther 1970;174:401412.
  • 55
    Yamanaka Y, Walsh MJ, Davis VE. Salsolinol, an alkaloid derivative of dopamine formed in vitro during alcohol metabolism. Nature 1970;227:11431144.
  • 56
    Turner AJ, Baker KM, Algeri S, Erigerio A, Garattini S. Tetrahydropapaveroline: Formation in vivo and in vitro in rat brain. Life Sci 1974;14:22472257.
  • 57
    Sandler M, Glover V, Armando I, Clow A. Pictet-Spengler condensation products, stress and alcoholism: Some clinical overtones. Prog Clin Biol Res 1982;90:215226.
  • 58
    Naoi M, Maruyama W, Nagy GM. Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: Occurrence, metabolism and function in human brains. Neurotoxicology 2004;25:193204.
  • 59
    Niwa T, Maruyama W, Nakahara D, et al. Endogenous synthesis of N-methylsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in rat brain during in vivo microdialysis with salsolinol, as demonstrated by gas chromatography-mass spectrometry. J Chromatogr 1992;578:109115.
  • 60
    Poeaknapo C, Schmidt J, Brandsch M, Drager B, Zenk MH. Endogenous formation of morphine in human cells. Proc Natl Acad Sci USA 2004;101:1409114096.
  • 61
    Boettcher C, Fellermeier M, Boettcher C, Drager B, Zenk MH. How human neuroblastoma cells make morphine. Proc Natl Acad Sci USA 2005;102:84958500.
  • 62
    Zhu W, Mantione KJ, Shen L, Lee B, Stefano GB. Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: Nicotine addiction. Cell Mol Neurobiol 2006;26:10371045.
  • 63
    Lind AB, Wadelius M, Darj E, Finnstrom N, Lundgren S, Rane A. Gene expression of cytochrome P450 1B1 and 2D6 in leukocytes in human pregnancy. Pharmacol Toxicol 2003;92:295299.
  • 64
    Hiroi T, Imaoka S, Funae Y. Dopamine formation from tyramine by CYP2D6. Biochem Biophys Res Commun 1998;249:838843.
  • 65
    Zhu W, Mantione KJ, Casares FM, et al. Alcohol-, nicotine-, and cocaine-evoked release of morphine from invertebrate ganglia: Model system for screening drugs of abuse. Med Sci Monit 2006;12:BR155BR161.
  • 66
    Zhu W, Mantione KJ, Casares FM, Sheehan MH, Kream RM, Stefano GB. Cholinergic regulation of endogenous morphine release from lobster nerve cord. Med Sci Monit 2006;12:BR295BR301.
  • 67
    Zhu W, Mantione K, Kream RM, Stefano GB. Alcohol-, nicotine-, and cocaine-evoked release of morphine from human white blood cells: Substances of abuse actions converge on endogenous morphine release. Med Sci Monit 2006;12:BR350BR354.
  • 68
    Stefano GB, Bianchi E, Guarna M, et al. Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: The dopamine-morphine hypothesis. Med Sci Monit 2007;13:RA91RA102.
  • 69
    Stefano GB, Scharrer B, Smith EM, et al. Opioid and opiate immunoregulatory processes. Crit Rev Immunol 1996;16:109144.
  • 70
    Stefano GB, Liu Y. Opiate antagonism of opioid actions on immunocyte activation and nitric oxide release. Anim Biol 1996;1:1116.
  • 71
    Pryor SC, Zhu W, Cadet P, Bianchi E, Guarna M, Stefano GB. Endogenous morphine: Opening new doors for the treatment of pain and addiction. Expert Opin Biol Ther 2005;5:893906.
  • 72
    Moncada S, Higgs A, Furchgott R. International union of pharmacology nomenclature in nitric oxide research. Pharmacol Rev 1997;49:137142.
  • 73
    Ignarro LJ. Signal transduction mechanisms involving nitric oxide. Biochem Pharmacol 1991;41:485490.
  • 74
    Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109142.
  • 75
    Moncada S, Higgs A. The L-arginine-nitric oxide pathway. New Eng J Med 1993;329:20022012.
  • 76
    Moncada S. Nitric oxide in the vasculature: Physiology and pathophysiology. Ann N Y Acad Sci 1997;811:6067.
  • 77
    Fimiani C, Liberty T, Aquirre AJ, Amin I, Ali N, Stefano GB. Opiate, cannabinoid, and eicosanoid signaling converges on common intracellular pathways: Nitric oxide coupling. Prostaglandins Other Lipid Mediat 1999;57:2334.
  • 78
    Welters ID, Fimiani C, Bilfinger TV, Stefano GB. NF-kB, nitric oxide and opiate signaling. Med Hypotheses 1999;54:263268.
  • 79
    Benz D, Cadet P, Mantione K, Zhu W, Stefano GB. Tonal nitric oxide and health: A free radical and a scavenger of free radicals. Med Sci Monit 2002;8:14.
  • 80
    Esch T, Stefano GB, Fricchione GL, Benson H. Stress-related diseases: A potential role for nitric oxide. Med Sci Monit 2002;8:RA103RA118.
  • 81
    Stefano GB, Esch T. Integrative medical therapy: Examination of meditation's therapeutic and global medicinal outcomes via nitric oxide (review). Int J Mol Med 2005;16:621630.
  • 82
    Tegeder I, Costigan M, Griffin RS, et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006;12:12691277.
  • 83
    Xu Q, Wink DA, Colton CA. Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. Exp Neurol 2004;188:341350.
  • 84
    Kato K, Giulivi C. Critical overview of mitochondrial nitric-oxide synthase. Front Biosci 2006;11:27252738.
  • 85
    Riobo NA, Melani M, Sanjuan N, et al. The modulation of mitochondrial nitric-oxide synthase activity in rat brain development. J Biol Chem 2002;277:4244742455.
  • 86
    Stefano GB, Digenis A, Spector S, et al. Opiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression. Proc Natl Acad Sci USA 1993;90:1109911103.
  • 87
    Cadet P, Mantione KJ, Stefano GB. Molecular identification and functional expression of mu3, a novel alternatively spliced variant of the human mu opiate receptor gene. J Immunol 2003;170:51185123.
  • 88
    Kream RM, Sheehan M, Cadet P, Mantione KJ, Zhu W, Casares FM, Stefano GB. Persistence of evolutionary memory: Primordial six-transmembrane helical domain mu opiate receptors selectively linked to endogenous morphine signaling. Med Sci Monit 2007;13:SC5SC6.
  • 89
    Cadet P, Mantione KJ, Zhu W, Kream RM, Sheehan M, Stefano GB. A functionally coupled mu3-like opiate receptor/nitric oxide regulatory pathway in human multi-lineage progenitor cells. J Immunol 2007;179:58395844.
  • 90
    Kotturi MF, Hunt SV, Jefferies WA. Roles of CRAC and Cav-like channels in T cells: More than one gatekeeper? Trends Pharmacol Sci 2006;27:360367.
  • 91
    Bozarth MA. Pleasure systems in the brain. In: WartburtonDM, ed. Pleasure: The politics and the reality. New York : Wiley & Sons, 1994;514.
  • 92
    Nestler EJ, Malenka RC. The addicted brain. Sci Am 2004;290:7885.
  • 93
    Stefano GB, Fricchione GL, Slingsby BT, Benson H. The placebo effect and relaxation response: Neural processes and their coupling to constitutive nitric oxide. Brain Res: Brain Res Rev 2001;35:119.
  • 94
    Hui KKS, Liu J, Makris N, et al. Acupuncture modulates the limbic system and subcortical gray structures of the human brain: Evidence from fMRI studies in normal subjects. Hum Brain Mapp 2000;9:1325.
  • 95
    Esch T, Stefano GB, Fricchione GL, Benson H. The role of stress in neurodegenerative diseases and mental disorders. Neuroendocrinol Lett 2002;23:199208.
  • 96
    Davidson RJ, Irwin W. The functional neuroanatomy of emotion and affective style. Trends Cogn Sci 1999;3:1121.
  • 97
    Esch T. Music medicine: Music in association with harm and healing. Musikphysiol Musikermed 2003;10:213224.
  • 98
    Nestler EJ. Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2001;2:119128.
  • 99
    Nestler EJ, Malenka RC, Hyman SE. Molecular basis of neuropharmacology. Columbus : McGraw-Hill, 2001.
  • 100
    Guarna M, Bianchi E, Bartolini A, et al. Endogenous morphine modulates acute thermonociception in mice. J Neurochem 2002;80:271277.
  • 101
    Rodriguez DF, Navarro M. Role of the limbic system in dependence on drugs. Ann Med 1998;30:397405.
  • 102
    Weiss F, Koob GF. Drug addiction: Functional neurotoxicity of the brain reward systems. Neurotox Res 2001;3:145156.
  • 103
    Esch T, Stefano GB. The neurobiology of pleasure, reward processes, addiction and their health implications. Neuroendocrinol Lett 2004;25:235251.
  • 104
    Bozarth MA. Ventral tegmental reward system. In: OrelandL, EngelJ, eds. Brain reward systems and abuse. New York : Raven Press, 1987;117.
  • 105
    Mitchell JB, Stewart J. Facilitation of sexual behaviors in the male rat associated with intra-VTA injections of opiates. Pharmacol Biochem Behav 1990;35:643650.
  • 106
    Hamilton ME, Bozarth MA. Feeding elicited by dynorphin (1–13) microinjections into the ventral tegmental area in rats. Life Sci 1988;43:941946.
  • 107
    Heath RG. Pleasure response of human subjects to direct stimulation of the brain. In: HeathRG, ed. The role of pleasure in human behavior. New York : Hoeber, 1964;219243.
  • 108
    Stefano GB, Scharrer B, Bilfinger TV, Salzet M, Fricchione GL. A novel view of opiate tolerance. Adv Neuroimmunol 1996;6:265277.
  • 109
    McClung CA, Nestler EJ. Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci 2003;6:12081215.
  • 110
    Zhang L, Lou D, Jiao H, et al. Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci 2004;24:33443354.
  • 111
    Murphy CA, Russig H, Pezze MA, Ferger B, Feldon J. Amphetamine withdrawal modulates FosB expression in mesolimbic dopaminergic target nuclei: Effects of different schedules of administration. Neuropharmacology 2003;44:926939.
  • 112
    Robinson TE, Berridge KC. Incentive-sensitization and addiction. Addiction 2001;96:103114.
  • 113
    Bozarth MA. New perspectives on cocaine addiction: Recent findings from animal research. Can J Physiol Pharmacol 1989;67:11581167.
  • 114
    Rossetti ZL, Hmaidan Y, Gessa GL. Marked inhibition of mesolimbic dopamine release: A common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats. Eur J Pharmacol 1992;221:227234.
  • 115
    Wise RA, Bozarth MA. A psychomotor stimulant theory of addiction. Psychol Rev 1987;94:469492.
  • 116
    Thompson AC, Kristal MB. Opioids in the ventral tegmental area facilitate the onset of maternal behavior in the rat. Soc Neurosci Abstr 1992;18:539.
  • 117
    Esch T, Guarna M, Bianchi E, Zhu W, Stefano GB. Commonalities in the central nervous system's involvement with complementary medical therapies: Limbic morphinergic processes. Med Sci Monit 2004;10:MS6MS17.
  • 118
    Esch T, Stefano GB. The neurobiology of love. Neuroendocrinol Lett 2005;26:175192.
  • 119
    Salamon E, Esch T, Stefano GB. The role of the amygdala in mediating sexual and emotional behavior via coupled nitric oxide release. Acta Pharmacologica Sinica 2005;26:389395.
  • 120
    Stefano GB, Fricchione GL, Esch T. Relaxation: Molecular and physiological significance. Med Sci Monit 2006;12:HY21HY31.
  • 121
    Davis VE, Walsh MJ. Alcohol, amines, and alkaloids: A possible biochemical basis for alcohol addiction. Science 1970;167:10051007.
  • 122
    Halushka PV, Hoffmann PC, Davis VE, Walsh MJ. Alcohol addiction and tetrahydropapaveroline. Science 1970;169:11041106.
  • 123
    Walsh MJ, Davis VE, Yamanaka Y. Tetrahydropapaveroline: An alkaloid metabolite of dopamine in vitro. J Pharmacol Exp Ther 1970;174:388400.
  • 124
    Weiner H. Relationship between 3,4-dihydroxyphenylacetaldehyde levels and tetrahydropapaveroline formation. Alcohol Clin Exp Res 1978;2:127131.
  • 125
    Collins MA, Hannigan JJ, Weiner C. Effects of catecholic tetrahydroisoquinolines on endogenous catecholamines. Curr Alcohol 1979;5:5359.
  • 126
    Weiner H. Possible steady-state concentrations of tetrahydroisoquinolines in brain after the consumption of ethanol. Fed Proc 1981;40:20822085.
  • 127
    Clow A, Stolerman IP, Murray RM, Sandler M. Ethanol preference in rats: Increased consumption after intraventricular administration of tetrahydropapaveroline. Neuropharmacology 1983;22:563565.
  • 128
    Myers RD. Anatomical “circuitry” in the brain mediating alcohol drinking revealed by THP-reactive sites in the limbic system. Alcohol 1990;7:449459.
  • 129
    Duncan CC, Fernando PW. Effects of tetrahydropapaveroline in the nucleus accumbens and the ventral tegmental area on ethanol preference in the rat. Alcohol 1991;8:8790.
  • 130
    Myers RD, Robinson DE. Tetrahydropapaveroline injected in the ventral tegmental area shifts dopamine efflux differentially in the shell and core of nucleus accumbens in high-ethanol-preferring (HEP) rats. Alcohol 1999;18:8390.
  • 131
    Sallstrom BS, Hill R, Kiianmaa K, Rommelspacher H. Effect of ethanol on (R)- and (S)-salsolinol, salsoline, and THP in the nucleus accumbens of AA and ANA rats. Alcohol 1999;18:165169.
  • 132
    Shearman GT, Herz A. Ethanol and tetrahydroisoquinoline alkaloids do not produce narcotic discriminative stimulus effects. Psychopharmacology (Berl) 1983;81:224227.
  • 133
    Haber H, Roske I, Rottmann M, Georgi M, Melzig MF. Alcohol induces formation of morphine precursors in the striatum of rats. Life Sci 1997;60:7989.
  • 134
    McCoy JG, Strawbridge C, McMurtrey KD, Kane VB, Ward CP. A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats. Brain Res Bull 2003;60:5965.
  • 135
    Heikkila R, Cohen G, Dembiec D. Tetrahydroisoquinoline alkaloids: Uptake by rat brain homogenates and inhibition of catecholamine uptake. J Pharmacol Exp Ther 1971;179:250258.
  • 136
    Greenberg RS, Cohen G. Tetrahydroisoquinoline alkaloids: Stimulated secretion from the adrenal medulla. J Pharmacol Exp Ther 1973;184:119128.
  • 137
    Katz S, Cohen G. A comparison of 6,7-dihydroxytetrahydroisoquinoline, salsolinol and tetrahydropapaveroline as inhibitors of monoamine oxidase within the adrenergic nerve plexus of the isolated mouse atrium. Res Commun Chem Pathol Pharmacol 1976;13:217224.
  • 138
    Britton DR. A convergent approach to the pharmacology of tetrahydroisoquinolines. Prog Clin Biol Res 1982;90:321326.
  • 139
    Suzuki K, Mizuno Y, Yoshida M. Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain. Neurochem Res 1990;15:705710.
  • 140
    Naoi M, Maruyama W, Kasamatsu T, Dostert P. Oxidation of N-methyl(R)salsolinol: Involvement to neurotoxicity and neuroprotection by endogenous catechol isoquinolines. J Neural Transm Suppl 1998;52:125138.
  • 141
    Collins MA. Tetrahydropapaveroline in Parkinson's disease and alcoholism: A look back in honor of Merton Sandler. Neurotoxicology 2004;25:117120.
  • 142
    Johnston GA. L-dopa and pyridoxal 5’-phosphate: Tetrahydroisoquinoline formation. Lancet 1971;297:1068.
  • 143
    Sandler M, Carter SB, Hunter KR, Stern GM. Tetrahydroisoquinoline alkaloids: In vivo metabolites of L-dopa in man. Nature 1973;241:439443.
  • 144
    Davis VE, Cashaw JL, McMurtrey KD. Disposition of catecholamine-derived alkaloids in mammalian systems. Adv Exp Med Biol 1975;59:6578.
  • 145
    Coscia CJ, Burke W, Jamroz G, et al. Occurrence of a new class of tetrahydroisoquinoline alkaloids in L-dopa-treated parkinsonian patients. Nature 1977;269:617619.
  • 146
    Matsubara K, Fukushima S, Akane A, Kobayashi S, Shiono H. Increased urinary morphine, codeine and tetrahydropapaveroline in parkinsonian patient undergoing L-3,4-dihydroxyphenylalanine therapy: A possible biosynthetic pathway of morphine from L-3,4-dihydroxyphenylalanine in humans. J Pharmacol Exp Ther 1992;260:974978.
  • 147
    Galloway MP, Burke WJ, Coscia CJ. Tetrahydroisoquinolinecarboxylic acids and catecholamine metabolism in adrenal medulla explants. Biochem Pharmacol 1982;31:32513256.
  • 148
    Nimit Y, Schulze I, Cashaw JL, Ruchirawat S, Davis VE. Interaction of catecholamine-derived alkaloids with central neurotransmitter receptors. J Neurosci Res 1983;10:175189.
  • 149
    Okada T, Shimada S, Sato K, et al. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells. Neurosci Res 1998;30:8790.
  • 150
    Soh Y, Shin MH, Lee JS, Jang JH, Kim OH, Kang H, Surh YJ. Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline. Mutat Res 2003;544:129142.
  • 151
    Shin MH, Jang JH, Surh YJ. Potential roles of NF-kappaB and ERK1/2 in cytoprotection against oxidative cell death induced by tetrahydropapaveroline. Free Radic Biol Med 2004;36:11851194.
  • 152
    Kim YM, Kim MN, Lee JJ, Lee MK. Inhibition of dopamine biosynthesis by tetrahydropapaveroline. Neurosci Lett 2005;386:14.
  • 153
    Cadet P, Zhu W, Mantione K, et al. Cyclic exercise induces anti-inflammatory signal molecule increases in the plasma of Parkinson's patients. Int J Mol Med 2003;12:485492.
  • 154
    Fricchione GL, Stefano GB. Placebo neural systems: Nitric oxide, morphine and the dopamine brain reward and motivation circuitries. Med Sci Monit 2005;11:MS54MS65.
  • 155
    Berg D, Becker G, Reiners K. Reduction of dyskinesia and induction of akinesia induced by morphine in two parkinsonian patients with severe sciatica. J Neural Transm 1999;106:725728.
  • 156
    Berg D, Becker G, Naumann M, Reiners K. Morphine in tardive and idiopathic dystonia (short communication). J Neural Transm 2001;108:10351041.
  • 157
    Stefano GB, Fricchione GL, Goumon Y, Esch T. Pain, immunity, opiate and opioid compounds and health. Med Sci Monit 2005;11:MS47MS53.
  • 158
    Esch T, Kim JW, Stefano GB. Neurobiological implications of eating healthy. Neuro Endocrinol Lett 2006;27:2133.
  • 159
    Stefano GB, Leung MK, Bilfinger TV, Scharrer B. Effect of prolonged exposure to morphine on responsiveness of human and invertebrate immunocytes to stimulatory molecules. J Neuroimmunol 1995;63:175181.
  • 160
    Stefano GB, Hartman A, Bilfinger TV, Magazine HI, Liu Y, Casares F, Goligorsky MS. Presence of the mu3 opiate receptor in endothelial cells: Coupling to nitric oxide production and vasodilation. J Biol Chem 1995;270:3029030293.
  • 161
    Stefano GB, Hartman A, Bilfinger TV, Magazine HI, Liu Y, Casares F, Goligorsky MS. Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation. J Biol Chem 1995;270:3029030293.
  • 162
    Mantione KJ, Cadet P, Zhu W, et al. Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: Autocrine/paracrine feedback inhibition. Addict Biol 2008;13:118123.
  • 163
    Stefano GB, Kream RM, Mantione KJ, et al. Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: Implications for cancer biology. Semin Cancer Biol 2008;18:199210.
  • 164
    Benz D, Cadet P, Mantione K, Zhu W, Stefano GB. Tonal nitric oxide and health: Anti-bacterial and -viral actions and implications for HIV. Med Sci Monit 2002;8:RA27RA31.