SHORT COMMUNICATION: Apolipoprotein E genotype and Cognition in Bipolar Disorder

Authors

  • Márcio Gerhardt Soeiro De Souza,

    1. Mood Disorders Unit (GRUDA), Department and Institute of Psychiatry, University of São Paulo, Faculty of Medicine, Brazil
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  • Danielle Soares Bio,

    1. Mood Disorders Unit (GRUDA), Department and Institute of Psychiatry, University of São Paulo, Faculty of Medicine, Brazil
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  • Vasco Videira Dias,

    1. Bipolar Disorder Research Program, Hospital Santa Maria, Faculty of Medicine, University of Lisbon, (FUML), Lisbon, Portugal
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  • Carolina Martins do Prado,

    1. Laboratory of Neuroscience (LIM27), Department and Institute of Psychiatry, University of São Paulo, Faculty of Medicine, Brazil
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  • Rodolfo Nunes Campos,

    1. Mood Disorders Unit (GRUDA), Department and Institute of Psychiatry, University of São Paulo, Faculty of Medicine, Brazil
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  • Luis Felipe de Oliveira Costa,

    1. Mood Disorders Unit (GRUDA), Department and Institute of Psychiatry, University of São Paulo, Faculty of Medicine, Brazil
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  • Doris Hupfeld Moreno,

    1. Mood Disorders Unit (GRUDA), Department and Institute of Psychiatry, University of São Paulo, Faculty of Medicine, Brazil
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  • Elida Benquique Ojopi,

    1. Laboratory of Neuroscience (LIM27), Department and Institute of Psychiatry, University of São Paulo, Faculty of Medicine, Brazil
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  • Wagner Farid Gattaz,

    1. Laboratory of Neuroscience (LIM27), Department and Institute of Psychiatry, University of São Paulo, Faculty of Medicine, Brazil
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  • Ricardo Alberto Moreno

    1. Mood Disorders Unit (GRUDA), Department and Institute of Psychiatry, University of São Paulo, Faculty of Medicine, Brazil
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Correspondence
Márcio Gerhardt Soeiro de Souza, Rua Dr. Ovídeo Pires de Campos, 785, CEAPESQ 3rd floor, North wing, room 12,
CEP 05403-010 São Paulo, Brazil.
Tel./Fax: +55 11 30696648;
E-mail: marciogss@hcnet.usp.br

Abstract

Apolipoprotein E (APOE) has been extensively studied as a risk factor for sporadic and late onset Alzheimer's Disease (AD). APOE allele*3, the most frequent variant, is not associated to cognitive dysfunction (CD) or to increased AD risk. Differently, the *4 allele is a well-established risk factor for CD, while the *2 allele is associated with survival and longevity. CD is an important feature of Bipolar Disorder (BD) and recent data suggest that CD may be one of its endophenotypes, although controversial results exist. The aim of this research is to study the association of APOE genotype (APOE) and neurocognitive function in a sample of drug free young BD-type I patients. Sample consisted of 25 symptomatic BD (type I) patients (age 18–35 years old). They were submitted to an extensive neuropsychological evaluation and genotyped for APOE. Subjects with allele*2 presented better cognitive performance. The presence of allele*4 was associated with worse performance in a few executive tasks. APOE*3*3 was associated with overall severe dysfunction on cognitive performance. In young individuals with nontreated BD-type I, APOE may predict cognitive performance. Further and larger studies on APOE and cognition in BD are required to clarify whether APOE is a BD cognitive endophenotype.

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