Failure of rasburicase therapy in recurrent acute gout with tophi


: Dr Catherine L. Hill, Rheumatology Unit, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville South Australia 5011. Email:


Rasburicase, a recombinant urate oxidase enzyme, has been used successfully in several cases of chronic tophaceous gout. We report the case of an elderly woman with chronic tophaceous gout who failed rasburicase therapy due to recurrent acute episodes of gout following each rasburicase infusion, despite prophylactic therapy.