Vitamin D deficiency and osteoporosis

Authors

  • Wei-Bo XIA,

    1. Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730 China and
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  • Ling XU,

    1. Department of Gynecology/Obstetrics, Peking Union Medical College hospital, Chinese Academy of Medical Sciences, Beijing 100730 China
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  • Hua SU

    1. Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730 China and
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: Weibo Xia, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sicences, Peking Union Medical College, Beijing 100730, China. Email: xiaweibo@medmail.com.cn

Abstract

Osteoporosis is a disease of disequilibrium between bone formation and bone loss, and vitamin D is one of the key hormones in the regulation of bone metabolism, the major role of which is to provide the proper micro-environment for bone mineralization. Vitamin D deficiency which has been defined by most experts as circulating 25-hydroxyvitamin D levels of less than 20 ng/mL (50 nmol/L) is widespread all over the world. As shown by the results of recent studies, vitamin D deficiency could increase the risk of low bone mineral density or osteoporosis, muscle disorders, falls, and as a matter of course, fractures due to both osteoporosis and falls. Long-term supplementation of vitamin D and calcium are good prevention measures for osteoporosis, falls and fractures. At the same time, they are essential components of osteoporosis management. Many studies show that sufficient vitamin D intake could increase bone mass, and decrease the risk of falls and fractures.

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