Elevated production of galectin-3 is correlated with juvenile idiopathic arthritis disease activity, severity, and progression
Article first published online: 28 JUL 2011
© 2011 The Authors. International Journal of Rheumatic Diseases © 2011 Asia Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty Ltd
International Journal of Rheumatic Diseases
Volume 14, Issue 4, pages 345–352, October 2011
How to Cite
EZZAT, M. H. M., EL-GAMMASY, T. M. A., SHAHEEN, K. Y. A. and OSMAN, A. O. Y. (2011), Elevated production of galectin-3 is correlated with juvenile idiopathic arthritis disease activity, severity, and progression. International Journal of Rheumatic Diseases, 14: 345–352. doi: 10.1111/j.1756-185X.2011.01632.x
- Issue published online: 17 OCT 2011
- Article first published online: 28 JUL 2011
- juvenile idiopathic arthritis;
Objectives: Galectin-3 is a carbohydrate-binding protein that plays many important regulatory roles in inflammation, immunity and cancers. Recent studies indicate that galectin-3 plays a role in rheumatoid arthritis (RA) pathogenesis and progression. Therefore, we sought to characterize the expression pattern and role of galectin-3 in juvenile idiopathic arthritis (JIA) and to explore whether galectin-3 investigated in serum and synovial fluid was associated with clinical, laboratory and radiological variables of JIA disease activity and severity.
Methods: Levels of galectin-3 in serum and synovial fluid from patients with JIA and controls were determined by enzyme-linked immunosorbent assay.
Results: Median (interquartile range) serum galectin-3 concentrations (ng/mL) were increasingly higher across the following groups: healthy controls (8.1 [4.9–16.7]), total JIA children with inactive disease (18.6 [9.7–28.8], P = 0.00039 vs. controls) and active disease (35.8 [15.8–60.8], P = 0.000012 vs. controls) (inactive vs. active, P = 0.00016). Highest serum expression was found in polyarthritic children. Galectin-3 concentrations in paired sera and synovial fluid samples could be related to each other. Serum and synovial concentrations of galectin-3 were positively correlated with total number of joints with active arthritis and with overall articular severity score. Patients with Larsen index and total radiographic score ≥ 1 had significant higher serum galectin-3 levels than patients with indices and scores < 1.
Conclusions: These results suggest that serum levels of galectin-3 are increased in active JIA children and galectin-3 can be a new biomarker indicating JIA disease activity, severity and progression, although its increment is not disease-specific.