Comparison of Naftopidil 75 mg with Tamsulosin Hydrochloride 0.2 mg in the Treatment of Lower Urinary Tract Symptoms with Benign Prostatic Hyperplasia
Article first published online: 29 MAR 2012
© 2012 Wiley Publishing Asia Pty Ltd
LUTS: Lower Urinary Tract Symptoms
Volume 4, Issue 3, pages 136–139, September 2012
How to Cite
SHIGEMURA, K., YAMAMICHI, F., MATSUMOTO, M., TANAKA, K., YAMASHITA, M., ARAKAWA, S. and FUJISAWA, M. (2012), Comparison of Naftopidil 75 mg with Tamsulosin Hydrochloride 0.2 mg in the Treatment of Lower Urinary Tract Symptoms with Benign Prostatic Hyperplasia. LUTS: Lower Urinary Tract Symptoms, 4: 136–139. doi: 10.1111/j.1757-5672.2012.00149.x
- Issue published online: 9 SEP 2012
- Article first published online: 29 MAR 2012
- Received 27 February 2011; revised 21 January 2012; accepted 22 February 2012.
- benign prostatic hyperplasia;
- lower urinary tract symptoms;
- naftopidil 75 mg;
- nocturia frequency;
- symptom scores
Objective: To compare the efficacy of two α1-adrenoceptor antagonists, α1D-adrenoceptor-selective naftopidil (Naf) 75 mg and α1A-adrenoceptor-selective tamsulosin hydrochloride (Tam) 0.2 mg, for the treatment of lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH).
Methods: Seventy-seven patients with LUTS secondary to BPH were enrolled. Data were gathered from patients retrospectively: 41 patients who were prescribed Naf 75 mg for 4 weeks and 36 patients who were prescribed Tam 0.2 mg for 4 weeks, respectively. The efficacy criteria were improvement in LUTS International Prostate Symptom Score (IPSS) and quality of life (QOL) scores after dosing.
Results: Naf 75 mg significantly improved symptoms in all 11 categories (overall IPSS, incomplete emptying, voiding symptoms [Intermittency, poor flow and straining], storage symptoms [daytime frequency, urgency and nocturia frequency], QOL index, intermittency, poor flow, straining, daytime frequency, urgency, and nocturia frequency) (P < 0.05). Tam 0.2 mg significantly suppressed 10 of the 11 tested symptom categories except straining (P < 0.05). Comparison data of the two drugs tended to show Naf 75 mg had better efficacy on nocturia frequency than Tam 0.2 mg (P < 0.05).
Conclusion: Naf 75 mg might show a better efficacy for LUTS with BPH in nocturia frequency than Tam 0.2 mg.