Effects of a group health promotion program on well-being and absenteeism of employees and skilled workers were tested. The objectives of the program are systematic self-monitoring and reflection on everyday life health behavior as well as the promotion of health- and development-related cognitions and well-being. Randomised group designs were employed to evaluate the program's effects on well-being, psychosomatic complaints, personal regulation of own development, and absenteeism. Program effects were confirmed with reference to these outcome measures administered at the end of the 8-week treatment and at 2-month follow-up in samples of 56 public employees (Study 1) and 39 skilled workers (Study 2). Results demonstrate the effectiveness and usability of the SySeRe program as an economical individual-level health promotion intervention in occupational health psychology with large effect sizes in psychometric measures of well-being and in the reduction of employee sick leave as well.