Present address: Vircell S.L. Polígono Ind, Dos de Octubre, Santa Fe, Granada 18320, Spain.
Fatty acid-mediated signalling between two Pseudomonas species
Article first published online: 7 MAY 2012
© 2012 Society for Applied Microbiology and Blackwell Publishing Ltd
Environmental Microbiology Reports
Special Issue: Ecology, Evolution and Population Genetics of Pathogenic Microbes
Volume 4, Issue 4, pages 417–423, August 2012
How to Cite
Fernández-Piñar, R., Espinosa-Urgel, M., Dubern, J.-F., Heeb, S., Ramos, J. L. and Cámara, M. (2012), Fatty acid-mediated signalling between two Pseudomonas species. Environmental Microbiology Reports, 4: 417–423. doi: 10.1111/j.1758-2229.2012.00349.x
- Issue published online: 16 JUL 2012
- Article first published online: 7 MAY 2012
- Received 30 January, 2012; revised 3 April, 2012; accepted 10 April, 2012.
We report the identification of fatty acids as mediators of intercellular signalling in Pseudomonas putida, and between Pseudomonas aeruginosa and P. putida. Tetradecanoic acid and fatty acids of similar chain length are present in supernatants of these strains and activate population density-dependent expression of ddcA, a gene involved in corn seed and root colonization by P. putida KT2440. Consistently, significant amounts of these compounds were also found in corn root exudates. The signalling pathway involves the two-component regulatory system formed by RoxS and RoxR, which had been previously shown to control expression of ddcA and of a set of genes related to the redox balance of P. putida cells. Production of the fatty acid signal in P. aeruginosa is under the control of the LasI/LasR and RhlI/RhlR quorum sensing systems. Our data indicate that in terms of cell–cell communication, P. putida KT2440 employs mechanisms closer to those of plant pathogens such as Xanthomonas spp. and fungi like Candida, which also rely on fatty acid derivatives.