Predictors of depression in Korean breast cancer patients: A one-year longitudinal study

Authors

  • Seon-Young Kim MD MSc,

    1. Mental Health Clinic, Chonnam National University Hwasun Hospital, Hwasun, Korea
    2. Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
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  • Robert Stewart MD MRCPsych,

    1. Institute of Psychiatry, King's College, London, UK
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  • Sung-Wan Kim MD PhD,

    1. Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
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  • Su-Jin Yang MD PhD,

    1. Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
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  • Jae-Min Kim MD PhD,

    Corresponding author
    1. Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
    • Mental Health Clinic, Chonnam National University Hwasun Hospital, Hwasun, Korea
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  • Il-Seon Shin MD PhD,

    1. Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
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  • Min-Ho Park MD PhD,

    1. Breast and Endocrine Tumor Clinic, Chonnam National University Hwasun Hospital, Hwasun, Korea
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  • Jung-Han Yoon MD PhD,

    1. Breast and Endocrine Tumor Clinic, Chonnam National University Hwasun Hospital, Hwasun, Korea
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  • Jin-Sang Yoon MD PhD

    1. Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
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Correspondence

Jae-Min Kim MD PhD, Department of Psychiatry, Chonnam National University Medical School, Gwangju 501-757, Korea.

Tel: +82 62 220 6143

Fax: +82 62 225 2351

Email: jmkim@chonnam.ac.kr

Abstract

Introduction

To investigate the prevalence, and 12-month persistence and incidence of depression following surgery for breast cancer and to determine factors associated with this in an East Asian setting.

Methods

All cases at a given hospital following surgery for breast cancer were approached and participants were interviewed 2–5 days after surgery. Depression (major and minor depressive disorders) was diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) using the Mini International Neuropsychiatric Interview at baseline and 12 months after surgery. Sociodemographic and clinical characteristics were investigated as covariates in logistic regression model.

Results

Of 335 breast cancer patients analyzed at baseline, 80 (23.9%) had prevalent depression. Persistence in those with depression at baseline (60 analyzed) was 33.3%; incidence of depression in those without depression at baseline (202 analyzed) was 13.4%. In adjusted logistic regression analyses, past and family histories of depression were significantly associated with depression on baseline, and number of metastatic axillary lymph nodes was associated with persistence of depression at follow-up. No factors were associated with incident depression.

Discussion

Depression is common among Korean women with breast cancer, and predictive factors for depression may differ according to the time after surgery.

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